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Completion Pneumonectomy: Outcomes for Benign and Malignant Indications #MMPMID23647859
Ann Thorac Surg 2013[Jun]; 95 (6): 1885-91 PMID23647859show ga
Background: Past series have identified completion pneumonectomy (CP) as a high-risk operation. We evaluated factors affecting outcomes of CP with a selective approach to offering this operation. Methods: We analyzed a prospective institutional database and abstracted information on patients undergoing pneumonectomy. Patients undergoing CP were compared to those undergoing primary pneumonectomy (PP). Results: Between 1/2000 and 2/2011, 211 patients underwent pneumonectomy, of which 35 (17%) were CPs. Ten of 35 (29%) CPs were for benign disease and 25/35 (71%) for cancer. Major perioperative morbidity was seen in 21/35 (60%) with 4 (11%) perioperative deaths. In univariate analysis, postoperative bronchopleural fistula (p=0.05) and benign diagnosis (p=0.07) tended to be associated with perioperative mortality.All 10 patients undergoing CP for benign disease developed a major complication compared to 11/25 (44%) with malignancy, p=0.002. A bronchopleural fistula (4/35, 11%) was more likely to occur in patients undergoing CP shortly after the primary operation (interval between lobectomy and CP; 0.28 vs. 4.5 years; p=0.018) with a trend towards a benign indication for operation (p=0.07). Median survival after CP for benign and malignant indications was 24.3 months and 36.5 months respectively.Comparing CP patients to those undergoing PP (n=176), CP patients were more likely to undergo surgery for benign disease (10/35, 29% vs. 14/176, 8%, p=0.001). Perioperative mortality for PP was 10/176 (5.7%), and was statistically similar to CP (11%). Conclusions: Despite a selective approach, CP remains a morbid operation particularly for benign indications. Rigorous preoperative optimization, ruling out contraindications to surgery and attention to technical detail are recommended.