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10.1369/0022155413482925 http://scihub22266oqcxt.onion/10.1369/0022155413482925 C3715326!3715326 !23456824     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23456824 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Histochem+Cytochem 2013 ; 61 (6 ): 433-43 Nephropedia Template TP {{tp|p=23456824 |t=2013. Losartan affects glomerular AKT and mTOR phosphorylation in an experimental model of type 1 diabetic nephropathy |pdf=|usr=}}{{23456824 }} gab.com Text Losartan affects glomerular AKT and mTOR phosphorylation in an experimental model of type 1 diabetic nephropathy JO: J Histochem Cytochem http://www.kidney.de/pget.php?&tw=1&pmid=23456824 #FOAvip The AKT-mTOR pathway is activated in diabetic nephropathy. Renin-angiotensin system modulators exert beneficial effects on the diabetic kidney. We explored the action of losartan on AKT-mTOR phosphorylation in glomeruli and podocytes. Diabetes mellitus was induced to Sprague-Dawley rats by streptozotocin. Five months later, the rats were commenced on losartan and euthanized 2 months later. Kidneys were processed for immunofluorescence studies. Glomeruli were isolated for Western blot analysis. Diabetes increased activated forms of AKT and mTOR both in glomeruli and podocytes. In diabetic rats, losartan decreased phosphorylated/activated forms of AKT (Thr308) and mTOR (Ser2448) in glomeruli but decreased only activated mTOR in podocytes. However, in both glomeruli and podocytes of healthy animals, an inverse pattern was evident. In conclusion, a new body of evidence indicates the differential activation of AKT-mTOR in glomeruli and podocytes of healthy and diabetic animals in response to losartan. Twit Text FOAVip Losartan affects glomerular AKT and mTOR phosphorylation in an experimental model of type 1 diabetic nephropathy ????J Histochem Cytochem http://www.kidney.de/pget.php?&tw=1&pmid=23456824 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23456824 #FOAvip English Wikipedia <ref>{{Cite pmid|23456824 }}</ref> Losartan affects glomerular AKT and mTOR phosphorylation in an experimental model of type 1 diabetic nephropathy #MMPMID23456824 Mavroeidi V ; Petrakis I ; Stylianou K ; Katsarou T ; Giannakakis K ; Perakis K ; Vardaki E ; Stratigis S ; Ganotakis E ; Papavasiliou S ; Daphnis E J Histochem Cytochem 2013[Jun]; 61 (6 ): 433-43 PMID23456824 show ga The AKT-mTOR pathway is activated in diabetic nephropathy. Renin-angiotensin system modulators exert beneficial effects on the diabetic kidney. We explored the action of losartan on AKT-mTOR phosphorylation in glomeruli and podocytes. Diabetes mellitus was induced to Sprague-Dawley rats by streptozotocin. Five months later, the rats were commenced on losartan and euthanized 2 months later. Kidneys were processed for immunofluorescence studies. Glomeruli were isolated for Western blot analysis. Diabetes increased activated forms of AKT and mTOR both in glomeruli and podocytes. In diabetic rats, losartan decreased phosphorylated/activated forms of AKT (Thr308) and mTOR (Ser2448) in glomeruli but decreased only activated mTOR in podocytes. However, in both glomeruli and podocytes of healthy animals, an inverse pattern was evident. In conclusion, a new body of evidence indicates the differential activation of AKT-mTOR in glomeruli and podocytes of healthy and diabetic animals in response to losartan. |*Disease Models, Animal [MESH] |Animals [MESH] |Diabetes Mellitus, Type 1/*drug therapy/metabolism/pathology [MESH] |Diabetic Nephropathies/*drug therapy/metabolism/pathology [MESH] |Kidney Glomerulus/*drug effects/metabolism/pathology [MESH] |Losartan/administration & dosage/*pharmacology [MESH] |Male [MESH] |Phosphorylation/drug effects [MESH] |Proto-Oncogene Proteins c-akt/*antagonists & inhibitors/metabolism [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Structure-Activity Relationship [MESH]Losartan affects glomerular AKT and mTOR phosphorylation in an experim(epmc).pdf DeepDyve Pubget Overpricing