Cancer Stem Cells Activate STAT3 the EZ Way #MMPMID23763996
Fouse SD; Costello JF
Cancer Cell 2013[Jun]; 23 (6): 711-3 PMID23763996show ga
Activated STAT3 and increased expression of the histone methyltransferase EZH2 are independently associated with the most malignant subset of gliomas. In this issue of Cancer Cell, Kim and colleagues discover that EZH2 enhances STAT3 activation by trimethylatinglysine 180 in STAT3 and does so preferentially in glioma stem-like cells.