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Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biophotonics 2013 ; 6 (ä): ä Nephropedia Template TP
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Magnetomotive photoacoustic imaging: in vitro studies of magnetic trapping with simultaneous photoacoustic detection of rare circulating tumor cells #MMPMID23420803
Wei Cw; Xia J; Pelivanov I; Jia C; Huang SW; Hu X; Gao X; O?Donnell M
J Biophotonics 2013[Jun]; 6 (ä): ä PMID23420803show ga
Photoacoustic (PA) imaging has been demonstrated to be a promising modality in molecular imaging for detection of nanoparticle-targeted diseased cells or tissues. However, intrinsic absorbers, such as blood, produce strong PA background signals that severely degrade the detection sensitivity and specificity of targeted objects. Magnetomotive photoacoustic (mmPA) imaging, a newly developed molecular imaging modality, introduced dynamic manipulation into traditional PA imaging. Unlike conventional PA imaging, magnetomotive manipulation with simultaneous ultrasound/PA imaging of agents incorporating magnetic nanoparticles enables direct visualization of the signal generating object and can dramatically reduce background signals from strong optical absorbers. This paper briefly reviews recent developments in mmPA imaging, including uses of composite contrast agent, design of magnet system, and data processing for motion filtering. The use of mmPA imaging in detecting rare circulating tumor cells in blood vessels, which remains a big challenge for real-time in vivo examination using current methodologies, was also addressed.Fusion Images (ultrasound + photoacousitc) of manipulation of magnetic-gold nanorod contrast agent targeted polystyrene beads in ink solution flowing with a rate of 12 ml/min [1]. Images (a) and (b) were acquired with a cone magnet array at two different positions, and (c) is the differential image of (a) and (b). A bipolar color scale is used to display the sign of the difference. Triangles indicate the magnet positions.