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2013 ; 6
(6-7
): 513-22
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Magnetomotive photoacoustic imaging: in vitro studies of magnetic trapping with
simultaneous photoacoustic detection of rare circulating tumor cells
#MMPMID23420803
Wei CW
; Xia J
; Pelivanov I
; Jia C
; Huang SW
; Hu X
; Gao X
; O'Donnell M
J Biophotonics
2013[Jun]; 6
(6-7
): 513-22
PMID23420803
show ga
Photoacoustic (PA) imaging has been demonstrated to be a promising modality in
molecular imaging for detection of nanoparticle-targeted diseased cells or
tissues. However, intrinsic absorbers, such as blood, produce strong PA
background signals that severely degrade the detection sensitivity and
specificity of targeted objects. Magnetomotive photoacoustic (mmPA) imaging, a
newly developed molecular imaging modality, introduced dynamic manipulation into
traditional PA imaging. Unlike conventional PA imaging, magnetomotive
manipulation with simultaneous ultrasound/PA imaging of agents incorporating
magnetic nanoparticles enables direct visualization of the signal generating
object and can dramatically reduce background signals from strong optical
absorbers. This paper briefly reviews recent developments in mmPA imaging,
including uses of composite contrast agent, design of magnet system, and data
processing for motion filtering. The use of mmPA imaging in detecting rare
circulating tumor cells in blood vessels, which remains a big challenge for
real-time in vivo examination using current methodologies, was also addressed.