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10.4049/jimmunol.1203302 http://scihub22266oqcxt.onion/10.4049/jimmunol.1203302 C3703618!3703618 !23667113     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23667113 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2013 ; 190 (12 ): 6115-25 Nephropedia Template TP {{tp|p=23667113 |t=2013. Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice |pdf=|usr=}}{{23667113 }} gab.com Text Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23667113 #FOAvip We examined the formation, participation, and functional specialization of virus-reactive Foxp3(+) regulatory T cells (Tregs) in a mouse model of influenza virus infection. "Natural" Tregs generated intrathymically, based on interactions with a self-peptide, proliferated in response to a homologous viral Ag in the lungs and, to a lesser extent, in the lung-draining mediastinal lymph nodes (medLNs) of virus-infected mice. In contrast, conventional CD4(+) T cells with identical TCR specificity underwent little or no conversion to become "adaptive" Tregs. The virus-reactive Tregs in the medLNs and the lungs of infected mice upregulated a variety of molecules associated with Treg activation, as well as acquired expression of molecules (T-bet, Blimp-1, and IL-10) that confer functional specialization to Tregs. Notably, however, the phenotypes of the T-bet(+) Tregs obtained from these sites were distinct, because Tregs isolated from the lungs expressed significantly higher levels of T-bet, Blimp-1, and IL-10 than did Tregs from the medLNs. Adoptive transfer of Ag-reactive Tregs led to decreased proliferation of antiviral CD4(+) and CD8(+) effector T cells in the lungs of infected hosts, whereas depletion of Tregs had a reciprocal effect. These studies demonstrate that thymically generated Tregs can become activated by a pathogen-derived peptide and acquire discrete T-bet(+) Treg phenotypes while participating in and modulating an antiviral immune response. Twit Text FOAVip Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23667113 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23667113 #FOAvip English Wikipedia <ref>{{Cite pmid|23667113 }}</ref> Viral antigen induces differentiation of Foxp3+ natural regulatory T cells in influenza virus-infected mice #MMPMID23667113 Bedoya F ; Cheng GS ; Leibow A ; Zakhary N ; Weissler K ; Garcia V ; Aitken M ; Kropf E ; Garlick DS ; Wherry EJ ; Erikson J ; Caton AJ J Immunol 2013[Jun]; 190 (12 ): 6115-25 PMID23667113 show ga We examined the formation, participation, and functional specialization of virus-reactive Foxp3(+) regulatory T cells (Tregs) in a mouse model of influenza virus infection. "Natural" Tregs generated intrathymically, based on interactions with a self-peptide, proliferated in response to a homologous viral Ag in the lungs and, to a lesser extent, in the lung-draining mediastinal lymph nodes (medLNs) of virus-infected mice. In contrast, conventional CD4(+) T cells with identical TCR specificity underwent little or no conversion to become "adaptive" Tregs. The virus-reactive Tregs in the medLNs and the lungs of infected mice upregulated a variety of molecules associated with Treg activation, as well as acquired expression of molecules (T-bet, Blimp-1, and IL-10) that confer functional specialization to Tregs. Notably, however, the phenotypes of the T-bet(+) Tregs obtained from these sites were distinct, because Tregs isolated from the lungs expressed significantly higher levels of T-bet, Blimp-1, and IL-10 than did Tregs from the medLNs. Adoptive transfer of Ag-reactive Tregs led to decreased proliferation of antiviral CD4(+) and CD8(+) effector T cells in the lungs of infected hosts, whereas depletion of Tregs had a reciprocal effect. These studies demonstrate that thymically generated Tregs can become activated by a pathogen-derived peptide and acquire discrete T-bet(+) Treg phenotypes while participating in and modulating an antiviral immune response. |Adoptive Transfer [MESH] |Animals [MESH] |Antigens, Viral/immunology [MESH] |Cell Differentiation/immunology [MESH] |Flow Cytometry [MESH] |Forkhead Transcription Factors/immunology [MESH] |Lymphocyte Activation/*immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Transgenic [MESH] |Orthomyxoviridae Infections/*immunology [MESH] |Orthomyxoviridae/immunology [MESH] |Phenotype [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |T-Lymphocyte Subsets/cytology/*immunology [MESH]Viral antigen induces differentiation of Foxp3+ natural regulatory T c(epmc).pdf DeepDyve Pubget Overpricing