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10.4049/jimmunol.1202382 http://scihub22266oqcxt.onion/10.4049/jimmunol.1202382 C3700538!3700538!23636058     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2013 ; 190 (11): 5402-10 Nephropedia Template TP {{tp|p=23636058|t=2013. Blockade of Programmed Death-1 (PD-1) in young (New Zealand Black × New Zealand White)F1 mice promotes the suppressive capacity of CD4+ regulatory T cells protecting from lupus-like disease |pdf=|usr=}}{{23636058}} gab.com Text Blockade of Programmed Death-1 (PD-1) in young (New Zealand Black × New Zealand White)F1 mice promotes the suppressive capacity of CD4+ regulatory T cells protecting from lupus-like disease JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23636058 #FOAvip PD-1 usually acts as a negative signal for T cell activation, and its expression on CD8+Foxp3+ T cells is required for their suppressive capacity. Here we show that PD-1 signalling is required for the maintenance of functional regulatory CD4+CD25+Foxp3+T cells (CD4+Treg) that can control autoimmunity in (New Zealand Black × New Zealand White) F1 (BWF1) lupus mice. PD-1 signalling induced resistance to apoptosis and prolonged the survival of CD4+Treg. In vivo, the blockade of PD-1 with a neutralizing antibody (Ab) reduced PD-1 expression on CD4+Treg (PD1loCD4+Treg). PD1loCD4+Treg had an increased ability to promote B cell apoptosis and to suppress CD4+ helper T cells (Th) as compared to CD4+Treg with elevated PD-1 expression (PD1hiCD4+Treg). When PD-1 expression on CD4+Treg was blocked in vitro, PD1loCD4+Treg suppressed B cell production of IgG and anti-dsDNA Ab. Finally, in vitro studies showed that the suppressive capacity of CD4+Treg depended on PD-1 expression, and that a fine tuning of the expression of this molecule directly affected cell survival and immune suppression. These results indicate that PD-1 expression has multiple effects on different immune cells that directly contribute to a modulation of autoimmune responses. Twit Text FOAVip Blockade of Programmed Death-1 (PD-1) in young (New Zealand Black × New Zealand White)F1 mice promotes the suppressive capacity of CD4+ regulatory T cells protecting from lupus-like disease ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23636058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23636058 #FOAvip English Wikipedia <ref>{{Cite pmid|23636058}}</ref> Blockade of Programmed Death-1 (PD-1) in young (New Zealand Black × New Zealand White)F1 mice promotes the suppressive capacity of CD4+ regulatory T cells protecting from lupus-like disease #MMPMID23636058 Wong M; Cava AL; Hahn BH J Immunol 2013[Jun]; 190 (11): 5402-10 PMID23636058show ga PD-1 usually acts as a negative signal for T cell activation, and its expression on CD8+Foxp3+ T cells is required for their suppressive capacity. Here we show that PD-1 signalling is required for the maintenance of functional regulatory CD4+CD25+Foxp3+T cells (CD4+Treg) that can control autoimmunity in (New Zealand Black × New Zealand White) F1 (BWF1) lupus mice. PD-1 signalling induced resistance to apoptosis and prolonged the survival of CD4+Treg. In vivo, the blockade of PD-1 with a neutralizing antibody (Ab) reduced PD-1 expression on CD4+Treg (PD1loCD4+Treg). PD1loCD4+Treg had an increased ability to promote B cell apoptosis and to suppress CD4+ helper T cells (Th) as compared to CD4+Treg with elevated PD-1 expression (PD1hiCD4+Treg). When PD-1 expression on CD4+Treg was blocked in vitro, PD1loCD4+Treg suppressed B cell production of IgG and anti-dsDNA Ab. Finally, in vitro studies showed that the suppressive capacity of CD4+Treg depended on PD-1 expression, and that a fine tuning of the expression of this molecule directly affected cell survival and immune suppression. These results indicate that PD-1 expression has multiple effects on different immune cells that directly contribute to a modulation of autoimmune responses. äBlockade of Programmed Death-1 (PD-1) in young (New Zealand Black × Ne(epmc).pdf DeepDyve Pubget Overpricing