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10.1681/ASN.2012080839 http://scihub22266oqcxt.onion/10.1681/ASN.2012080839 C3699826!3699826!23599382     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23599382&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2013 ; 24 (7): 1053-62 Nephropedia Template TP {{tp|p=23599382|t=2013. Deficiency of Renal Cortical EGF Increases ENaC Activity and Contributes to Salt-Sensitive Hypertension |pdf=|usr=}}{{23599382}} gab.com Text Deficiency of Renal Cortical EGF Increases ENaC Activity and Contributes to Salt-Sensitive Hypertension JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=23599382 #FOAvip Various stimuli, including hormones and growth factors, modulate epithelial sodium channels (ENaCs), which fine-tune Na+ absorption in the kidney. Members of the EGF family are important for maintaining transepithelial Na+ transport, but whether EGF influences ENaC, perhaps mediating salt-sensitive hypertension, is not well understood. Here, the ENaC inhibitor benzamil attenuated the development of hypertension in Dahl salt-sensitive rats. Feeding these salt-sensitive rats a high-salt diet led to lower levels of EGF in the kidney cortex and enhanced the expression and activity of ENaC compared with feeding a low-salt diet. To directly evaluate the role of EGF in the development of hypertension and its effect on ENaC activity, we infused EGF intravenously while continuously monitoring BP of the salt-sensitive rats. Infusion of EGF decreased ENaC activity, prevented the development of hypertension, and attenuated glomerular and renal tubular damage. Taken together, these findings indicate that cortical EGF levels decrease with a high-salt diet in salt-sensitive rats, promoting ENaC-mediated Na+ reabsorption in the collecting duct and the development of hypertension. Twit Text FOAVip Deficiency of Renal Cortical EGF Increases ENaC Activity and Contributes to Salt-Sensitive Hypertension ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=23599382 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23599382 #FOAvip English Wikipedia <ref>{{Cite pmid|23599382}}</ref> Deficiency of Renal Cortical EGF Increases ENaC Activity and Contributes to Salt-Sensitive Hypertension #MMPMID23599382 Pavlov TS; Levchenko V; O?Connor PM; Ilatovskaya DV; Palygin O; Mori T; Mattson DL; Sorokin A; Lombard JH; Cowley AW; Staruschenko A J Am Soc Nephrol 2013[Jun]; 24 (7): 1053-62 PMID23599382show ga Various stimuli, including hormones and growth factors, modulate epithelial sodium channels (ENaCs), which fine-tune Na+ absorption in the kidney. Members of the EGF family are important for maintaining transepithelial Na+ transport, but whether EGF influences ENaC, perhaps mediating salt-sensitive hypertension, is not well understood. Here, the ENaC inhibitor benzamil attenuated the development of hypertension in Dahl salt-sensitive rats. Feeding these salt-sensitive rats a high-salt diet led to lower levels of EGF in the kidney cortex and enhanced the expression and activity of ENaC compared with feeding a low-salt diet. To directly evaluate the role of EGF in the development of hypertension and its effect on ENaC activity, we infused EGF intravenously while continuously monitoring BP of the salt-sensitive rats. Infusion of EGF decreased ENaC activity, prevented the development of hypertension, and attenuated glomerular and renal tubular damage. Taken together, these findings indicate that cortical EGF levels decrease with a high-salt diet in salt-sensitive rats, promoting ENaC-mediated Na+ reabsorption in the collecting duct and the development of hypertension. äDeficiency of Renal Cortical EGF Increases ENaC Activity and Contribut(epmc).pdf DeepDyve Pubget Overpricing