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10.1074/jbc.M113.466748

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C3696681!3696681!23673663
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suck abstract from ncbi


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pmid23673663      J+Biol+Chem 2013 ; 288 (26): 19081-9
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  • The Antiprion Compound 6-Aminophenanthridine Inhibits the Protein Folding Activity of the Ribosome by Direct Competition* #MMPMID23673663
  • Pang Y; Kurella S; Voisset C; Samanta D; Banerjee D; Schabe A; Das Gupta C; Galons H; Blondel M; Sanyal S
  • J Biol Chem 2013[Jun]; 288 (26): 19081-9 PMID23673663show ga
  • Background: 6-Aminophenanthridine (6AP) is an inhibitor of the protein folding activity of the ribosome (PFAR).Results: The protein substrates and 6AP bind at common sites on rRNA; mutations at those sites abolish binding and inhibit PFAR.Conclusion: 6AP competitively obstructs the protein-binding sites and thereby inhibits PFAR.Significance: We have clarified the mechanism by which 6AP inhibits PFAR.
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