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10.1074/jbc.M113.465450

http://scihub22266oqcxt.onion/10.1074/jbc.M113.465450
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C3696664!3696664!23665562
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suck abstract from ncbi


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pmid23665562      J+Biol+Chem 2013 ; 288 (26): 18885-93
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  • Synip Arrests Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (SNARE)-dependent Membrane Fusion as a Selective Target Membrane SNARE-binding Inhibitor* #MMPMID23665562
  • Yu H; Rathore SS; Shen J
  • J Biol Chem 2013[Jun]; 288 (26): 18885-93 PMID23665562show ga
  • Background: Synip is a SNARE-binding regulatory factor whose molecular mechanism remains unclear.Results: Synip acts as a selective t-SNARE-binding inhibitor that arrests membrane fusion by preventing the initiation of ternary SNARE complex assembly.Conclusion: Synip function likely represents a novel regulatory mechanism of vesicle fusion.Significance: Studies of vesicle fusion regulation provide key insights into the mechanisms of vesicle transport.
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