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10.1093/ajh/hpt026

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C3693479!3693479!23535155
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suck abstract from ncbi


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pmid23535155      Am+J+Hypertens 2013 ; 26 (6): 822-8
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  • Day/Night Variability in Blood Pressure: Influence of Posture and Physical Activity #MMPMID23535155
  • Morris CJ; Hastings JA; Boyd K; Krainski F; Perhonen MA; Scheer FA; Levine BD
  • Am J Hypertens 2013[Jun]; 26 (6): 822-8 PMID23535155show ga
  • BACKGROUND: Blood pressure (BP) is highest during the day and lowest at night. Absence of this rhythm is a predictor of cardiovascular morbidity and mortality. Contributions of changes in posture and physical activity to the 24-hour day/night rhythm in BP are not well understood. We hypothesized that postural changes and physical activity contribute substantially to the day/night rhythm in BP. METHODS: Fourteen healthy, sedentary, nonobese, normotensive men (aged 19?50 years) each completed an ambulatory and a bed rest condition during which BP was measured every 30?60 minutes for 24 hours. When ambulatory, subjects followed their usual routines without restrictions to capture the ?normal? condition. During bed rest, subjects were constantly confined to bed in a 6-degree head-down position; therefore posture was constant, and physical activity was minimized. Two subjects were excluded from analysis because of irregular sleep timing. RESULTS: The systolic and diastolic BP reduction during the sleep period was similar in ambulatory (?11±2mmHg/?8±1mmHg) and bed rest conditions (?8±3mmHg/?4±2mmHg; P = 0.38/P = 0.12). The morning surge in diastolic BP was attenuated during bed rest (P = 0.001), and there was a statistical trend for the same effect in systolic BP (P = 0.06). CONCLUSIONS: A substantial proportion of the 24-hour BP rhythm remained during bed rest, indicating that typical daily changes in posture and/or physical activity do not entirely explain 24-hour BP variation under normal ambulatory conditions. However, the morning BP increase was attenuated during bed rest, suggesting that the adoption of an upright posture and/or physical activity in the morning contributes to the morning BP surge.
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