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EMERGING FUNGAL INFECTIONS IN SOLID ORGAN TRANSPLANT RECIPIENTS #MMPMID23714342
Shoham S
Infect Dis Clin North Am 2013[Jun]; 27 (2): 305-16 PMID23714342show ga
The most important emerging and rare fungal pathogens in solid organ transplant recipients are the Zygomycetes, Scedosporium, Fusarium and the dark molds. Factors impacting the emergence of these fungi include the combination of intensive immunosuppressive regimens with increasingly widespread use of long-term azole antifungal therapy; employment of aggressive diagnostic approaches (e.g. sampling of bronchoalveolar lavage fluid) and changes in patients? interactions with the environment. Early diagnosis, differentiation between colonization and infection and institution of appropriate therapy is vital when contending with these fungi. Moreover, effective treatment often requires a multi-disciplinary approach. This article reviews the epidemiology, microbiology and clinical impact of emerging fungal infections in solid organ transplant recipients and provides up to date recommendations on their treatment.