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10.1074/jbc.M112.438762

http://scihub22266oqcxt.onion/10.1074/jbc.M112.438762
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C3689981!3689981!23645672
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suck abstract from ncbi


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pmid23645672      J+Biol+Chem 2013 ; 288 (25): 18393-405
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  • Seven in Absentia Homolog 2 (Siah2) Protein Is a Regulator of NF-E2-related Factor 2 (Nrf2)*? #MMPMID23645672
  • Baba K; Morimoto H; Imaoka S
  • J Biol Chem 2013[Jun]; 288 (25): 18393-405 PMID23645672show ga
  • Background: Nrf2 is up-regulated in response to reoxygenation after hypoxia.Results: Hypoxia suppressed Nrf2 expression and induced Siah2 expression. Knockdown of Siah2 rescued hypoxic suppression of an Nrf2 mutant that mimicked phosphorylation at serine 40 or lacked this phosphorylation site.Conclusion: Siah2 serves as a novel regulator of Nrf2.Significance: Association of Siah2 with Nrf2 causes the degradation of Nrf2 irrespective of its phosphorylation status at serine 40.
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