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10.1074/jbc.M113.475277

http://scihub22266oqcxt.onion/10.1074/jbc.M113.475277
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C3689941!3689941!23653350
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suck abstract from ncbi


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pmid23653350      J+Biol+Chem 2013 ; 288 (25): 17954-67
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  • Epithelial to Mesenchymal Transition Promotes Breast Cancer Progression via a Fibronectin-dependent STAT3 Signaling Pathway* #MMPMID23653350
  • Balanis N; Wendt MK; Schiemann BJ; Wang Z; Schiemann WP; Carlin CR
  • J Biol Chem 2013[Jun]; 288 (25): 17954-67 PMID23653350show ga
  • Background: Cells perceive their environment through soluble growth factors and in response to extracellular matrix.Results: STAT3 signaling can be activated by multiple pathways during breast cancer progression.Conclusion: Fibronectin:STAT3 signaling promotes three-dimensional outgrowth of breast cancer cells.Significance: This study demonstrates a novel mechanism by which STAT3 becomes activated by the extracellular matrix independent of the canonical EGF receptor signaling network.
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