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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Chem+Neurosci 2013 ; 4 (6): 983-93 Nephropedia Template TP
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The Molecular Basis of Memory Part 2: Chemistry of the Tripartite Mechanism #MMPMID23419130
Marx G; Gilon C
ACS Chem Neurosci 2013[Jun]; 4 (6): 983-93 PMID23419130show ga
We propose a tripartite mechanism to describe the processing of cognitive information (cog-info), comprising the (1) neuron, (2) surrounding neural extracellular matrix (nECM), and (3) numerous ?trace? metals distributed therein. The neuron is encased in a polyanionic nECM lattice doped with metals (>10), wherein it processes (computes) and stores cog-info. Each [nECM:metal] complex is the molecular correlate of a cognitive unit of information (cuinfo), similar to a computer ?bit?. These are induced/sensed by the neuron via surface iontophoretic and electroelastic (piezoelectric) sensors. The generic cuinfo are used by neurons to biochemically encode and store cog-info in a rapid, energy efficient, but computationally expansive manner. Here, we describe chemical reactions involved in various processes that underline the tripartite mechanism. In addition, we present novel iconographic representations of various types of cuinfo resulting from?tagging? and cross-linking reactions, essential for the indexing cuinfo for organized retrieval and storage of memory.