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10.1089/jmf.2012.0175 http://scihub22266oqcxt.onion/10.1089/jmf.2012.0175 C3684211!3684211 !23734997     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23734997 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Med+Food 2013 ; 16 (6 ): 518-28 Nephropedia Template TP {{tp|p=23734997 |t=2013. Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl?-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression |pdf=|usr=}}{{23734997 }} gab.com Text Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl -intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression JO: J Med Food http://www.kidney.de/pget.php?&tw=1&pmid=23734997 #FOAvip Liver fibrosis is the result of chronic liver injury, and it represents a widespread medical problem. The aim of this study is to investigate the antifibrotic activity of isoquinoline alkaloid berberine in carbon tetrachloride (CCl?)-induced damage in mice. Hepatic fibrosis was induced by intraperitoneal (i.p.) administration of CCl? (2?mL/kg, 20% v/v in olive oil) twice a week for 8 weeks. Berberine at the doses of 3 and 9?mg/kg and silymarin at the dose of 50?mg/kg were given i.p. once daily for the next 2 weeks. CCl? intoxication increased the levels of serum transaminases and induced oxidative stress in the liver. Hepatic fibrosis was evidenced by a massive deposition of collagen, which coincided with increased expression of tumor necrosis factor (TNF)-? and transforming growth factor (TGF)-?1 and the activation of hepatic stellate cells. The high-dose berberine (9?mg/kg) ameliorated oxidative stress, decreased TNF-? and TGF-?1 expression, increased the levels of matrix metalloproteinase (MMP)-2, and stimulated the elimination of fibrous deposits. Berberine at the dose of 9?mg/kg exhibited stronger therapeutic activity against hepatic fibrosis than silymarin at the dose of 50?mg/kg. In vitro analyses show an important scavenging activity of berberine against oxygen and nitrogen reactive species. The results of this study suggest that berberine could ameliorate liver fibrosis through the suppression of hepatic oxidative stress and fibrogenic potential, concomitantly stimulating the degradation of collagen deposits by MMP-2. Twit Text FOAVip Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl -intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression ????J Med Food http://www.kidney.de/pget.php?&tw=1&pmid=23734997 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23734997 #FOAvip English Wikipedia <ref>{{Cite pmid|23734997 }}</ref> Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl?-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression #MMPMID23734997 Domitrovi? R ; Jakovac H ; Marchesi VV ; Bla?ekovi? B J Med Food 2013[Jun]; 16 (6 ): 518-28 PMID23734997 show ga Liver fibrosis is the result of chronic liver injury, and it represents a widespread medical problem. The aim of this study is to investigate the antifibrotic activity of isoquinoline alkaloid berberine in carbon tetrachloride (CCl?)-induced damage in mice. Hepatic fibrosis was induced by intraperitoneal (i.p.) administration of CCl? (2?mL/kg, 20% v/v in olive oil) twice a week for 8 weeks. Berberine at the doses of 3 and 9?mg/kg and silymarin at the dose of 50?mg/kg were given i.p. once daily for the next 2 weeks. CCl? intoxication increased the levels of serum transaminases and induced oxidative stress in the liver. Hepatic fibrosis was evidenced by a massive deposition of collagen, which coincided with increased expression of tumor necrosis factor (TNF)-? and transforming growth factor (TGF)-?1 and the activation of hepatic stellate cells. The high-dose berberine (9?mg/kg) ameliorated oxidative stress, decreased TNF-? and TGF-?1 expression, increased the levels of matrix metalloproteinase (MMP)-2, and stimulated the elimination of fibrous deposits. Berberine at the dose of 9?mg/kg exhibited stronger therapeutic activity against hepatic fibrosis than silymarin at the dose of 50?mg/kg. In vitro analyses show an important scavenging activity of berberine against oxygen and nitrogen reactive species. The results of this study suggest that berberine could ameliorate liver fibrosis through the suppression of hepatic oxidative stress and fibrogenic potential, concomitantly stimulating the degradation of collagen deposits by MMP-2. |Animals [MESH] |Berberine/*administration & dosage [MESH] |Carbon Tetrachloride/adverse effects [MESH] |Hepatic Stellate Cells/drug effects/metabolism [MESH] |Humans [MESH] |Isoquinolines/*administration & dosage [MESH] |Liver Cirrhosis/*drug therapy/enzymology/metabolism [MESH] |Male [MESH] |Matrix Metalloproteinase 2/*genetics/metabolism [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Oxidative Stress/*drug effects [MESH] |Transforming Growth Factor beta1/genetics/metabolism [MESH] |Tumor Necrosis Factor-alpha/genetics/metabolism [MESH]Resolution of liver fibrosis by isoquinoline alkaloid berberine in C(epmc).pdf DeepDyve Pubget Overpricing