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10.1101/cshperspect.a012583 http://scihub22266oqcxt.onion/10.1101/cshperspect.a012583 C3683898!3683898!23545420     free     free     free       Cold+Spring+Harb+Perspect+Biol 2013 ; 5 (4): ä Nephropedia Template TP {{tp|p=23545420|t=2013. Base Excision Repair |pdf=|usr=}}{{23545420}} gab.com Text Base Excision Repair JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=23545420 #FOAvip Base excision repair (BER) corrects DNA damage from oxidation, deamination and alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is initiated by a DNA glycosylase that recognizes and removes the damaged base, leaving an abasic site that is further processed by short-patch repair or long-patch repair that largely uses different proteins to complete BER. At least 11 distinct mammalian DNA glycosylases are known, each recognizing a few related lesions, frequently with some overlap in specificities. Impressively, the damaged bases are rapidly identified in a vast excess of normal bases, without a supply of energy. BER protects against cancer, aging, and neurodegeneration and takes place both in nuclei and mitochondria. More recently, an important role of uracil-DNA glycosylase UNG2 in adaptive immunity was revealed. Furthermore, other DNA glycosylases may have important roles in epigenetics, thus expanding the repertoire of BER proteins. Twit Text FOAVip Base Excision Repair ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=23545420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23545420 #FOAvip English Wikipedia <ref>{{Cite pmid|23545420}}</ref> Base Excision Repair #MMPMID23545420 Krokan HE; Bjørås M Cold Spring Harb Perspect Biol 2013[Apr]; 5 (4): ä PMID23545420show ga Base excision repair (BER) corrects DNA damage from oxidation, deamination and alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is initiated by a DNA glycosylase that recognizes and removes the damaged base, leaving an abasic site that is further processed by short-patch repair or long-patch repair that largely uses different proteins to complete BER. At least 11 distinct mammalian DNA glycosylases are known, each recognizing a few related lesions, frequently with some overlap in specificities. Impressively, the damaged bases are rapidly identified in a vast excess of normal bases, without a supply of energy. BER protects against cancer, aging, and neurodegeneration and takes place both in nuclei and mitochondria. More recently, an important role of uracil-DNA glycosylase UNG2 in adaptive immunity was revealed. Furthermore, other DNA glycosylases may have important roles in epigenetics, thus expanding the repertoire of BER proteins. äBase Excision Repair (epmc).pdf DeepDyve Pubget Overpricing