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10.1074/jbc.M112.448977

http://scihub22266oqcxt.onion/10.1074/jbc.M112.448977
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C3682582!3682582!23667253
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suck abstract from ncbi


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pmid23667253      J+Biol+Chem 2013 ; 288 (24): 17832-43
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  • The Hbs1-Dom34 Protein Complex Functions in Non-stop mRNA Decay in Mammalian Cells* #MMPMID23667253
  • Saito S; Hosoda N; Hoshino Si
  • J Biol Chem 2013[Jun]; 288 (24): 17832-43 PMID23667253show ga
  • Background: The non-stop decay (NSD) mechanism has remained undetermined in mammalian cells.Results: Degradation of unstable non-stop mRNA requires Hbs1, Dom34, and the exosome-Ski complex in mammalian cells.Conclusion: The NSD mechanism exists in mammalian cells and involves a member of the eRF3 family of G proteins, Hbs1.Significance: Our work provides a foundation for dissecting the detailed molecular basis of the human NSD mechanism.
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