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10.1074/jbc.M113.453548

http://scihub22266oqcxt.onion/10.1074/jbc.M113.453548
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C3682572!3682572!23609447
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suck abstract from ncbi


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pmid23609447      J+Biol+Chem 2013 ; 288 (24): 17725-33
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  • Attenuated Natural Killer (NK) Cell Activation through C-type Lectin-like Receptor NKp80 Is Due to an Anomalous Hemi-immunoreceptor Tyrosine-based Activation Motif (HemITAM) with Impaired Syk Kinase Recruitment Capacity* #MMPMID23609447
  • Rückrich T; Steinle A
  • J Biol Chem 2013[Jun]; 288 (24): 17725-33 PMID23609447show ga
  • Background: The activating NK receptor NKp80 triggers cytotoxicity by human NK cells via a cytoplasmic hemITAM sequence.Results: A non-consensus hemITAM residue impairs the capacity of NKp80 to recruit Syk kinase and to trigger cytotoxicity.Conclusion: Unlike typical hemITAM receptors, NKp80 does not efficiently recruit Syk kinase resulting in attenuated effector responses.Significance: An attenuated cytotoxic responsiveness critically impacts on the immunomodulatory function of NKp80.
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