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10.1074/jbc.M113.467498

http://scihub22266oqcxt.onion/10.1074/jbc.M113.467498
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C3682558!3682558!23645682
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suck abstract from ncbi


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pmid23645682      J+Biol+Chem 2013 ; 288 (24): 17589-96
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  • Specific Requirement of Gli Transcription Factors in Hedgehog-mediated Intestinal Development* #MMPMID23645682
  • Huang H; Cotton JL; Wang Y; Rajurkar M; Zhu LJ; Lewis BC; Mao J
  • J Biol Chem 2013[Jun]; 288 (24): 17589-96 PMID23645682show ga
  • Background: Hedgehog signaling plays important roles during intestinal development.Results: Mesenchymal Gli2 activation, but not Gli3 removal, rescued Hedgehog pathway defects. Screen identified small leucine-rich glycoproteins (SLRPs) downstream of Hedgehog in the gut.Conclusion: Hedgehog activity is mediated by Gli2 and involves SLRP regulation in the developing intestine.Significance: This study uncovers novel genetic and molecular mechanisms underlying Hedgehog function in intestinal development.
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