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10.1074/jbc.M112.445965

http://scihub22266oqcxt.onion/10.1074/jbc.M112.445965
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C3682526!3682526!23620592
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suck abstract from ncbi


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pmid23620592      J+Biol+Chem 2013 ; 288 (24): 17214-24
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  • Wnt/?-Catenin Signaling Protects Mouse Liver against Oxidative Stress-induced Apoptosis through the Inhibition of Forkhead Transcription Factor FoxO3* #MMPMID23620592
  • Tao GZ; Lehwald N; Jang KY; Baek J; Xu B; Omary MB; Sylvester KG
  • J Biol Chem 2013[Jun]; 288 (24): 17214-24 PMID23620592show ga
  • Background: Wnt/?-catenin signaling regulates various hepatocellular processes; however, it remains unexplored whether ?-catenin provides hepatocyte protection against oxidative stress-induced apoptosis.Results: Mice with ?-catenin-deficient hepatocytes demonstrate significantly increased hepatotoxin-induced liver injury.Conclusion: Hepatic ?-catenin signaling confers hepatocyte protection against oxidative stress-induced apoptosis.Significance: Our findings have relevance for potential future therapies directed at hepatocyte protection, regeneration, and anti-cancer treatment.
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