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2013 ; 304
(12
): R1166-74
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Role of pituitary in K+ homeostasis: impaired renal responses to altered K+
intake in hypophysectomized rats
#MMPMID23594607
Oh YT
; Kim J
; Youn JH
Am J Physiol Regul Integr Comp Physiol
2013[Jun]; 304
(12
): R1166-74
PMID23594607
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The kidneys maintain extracellular K? homeostasis by altering K? excretion to
match K? intake. Because this can occur without changes in plasma K?
concentrations ([K?]), how the kidneys sense K? intake is unclear. We tested the
hypothesis that the pituitary plays a critical role in signaling K? intake to the
kidneys. If this hypothesis is true, hypophysectomy would impair kidney responses
to altered K? intake. Hypophysectomized (Hypox) and sham-operated control rats (n
= 8 each) were compared for their abilities to adjust K? excretion during a
transition from normal to reduced (to one-third of normal) K? intake, followed by
a reversal to normal K? intake. Food was provided only at night, and renal K?
excretion was determined both for absorptive (night or feeding) and
postabsorptive (day or nonfeeding) periods. In normal rats, both absorptive and
postabsorptive renal K? excretion were changed in parallel to the changes in K?
intake, indicating a rapid adaptation of normal kidneys to altered K? intake. In
Hypox rats, whereas absorptive renal K? excretion was changed in response to
changes in K? intake, postabsorptive K? excretion was not responsive (P < 0.001),
indicating impaired renal responses to altered K? intake. In addition, Hypox
rats, compared with control rats, showed K? intolerance (increases in plasma
[K?]) upon feeding (i.e., K? intake) at night or following an intravenous K?
infusion (P < 0.01), indicating an impairment of acute renal responses to K?
intake. These data support that the pituitary plays a key role in the signaling
of K? intake to the kidneys (and kidney responses to altered K? intake).
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