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10.1152/ajpregu.00368.2012 http://scihub22266oqcxt.onion/10.1152/ajpregu.00368.2012 C3680792!3680792 !23576617     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23576617 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Regul+Integr+Comp+Physiol 2013 ; 304 (12 ): R1085-95 Nephropedia Template TP {{tp|p=23576617 |t=2013. Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite |pdf=|usr=}}{{23576617 }} gab.com Text Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite JO: Am J Physiol Regul Integr Comp Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23576617 #FOAvip Disruption of finely coordinated neuropeptide signals in the hypothalamus can result in altered food intake and body weight. We identified neuron-derived neurotrophic factor (NENF) as a novel secreted protein through a large-scale screen aimed at identifying novel secreted hypothalamic proteins that regulate food intake. We observed robust Nenf expression in hypothalamic nuclei known to regulate food intake, and its expression was altered under the diet-induced obese (DIO) condition relative to the fed state. Hypothalamic Nenf mRNA was regulated by brain-derived neurotrophic factor (BDNF) signaling, itself an important regulator of appetite. Delivery of purified recombinant BDNF into the lateral cerebral ventricle decreased hypothalamic Nenf expression, while pharmacological inhibition of trkB signaling increased Nenf mRNA expression. Furthermore, recombinant NENF administered via an intracerebroventricular cannula decreased food intake and body weight and increased hypothalamic Pomc and Mc4r mRNA expression. Importantly, the appetite-suppressing effect of NENF was abrogated in obese mice fed a high-fat diet, demonstrating a diet-dependent modulation of NENF function. We propose the existence of a regulatory circuit involving BDNF, NENF, and melanocortin signaling. Our study validates the power of using an integrated experimental and bioinformatic approach to identify novel CNS-derived proteins with appetite-modulating function and reveals NENF as an important central modulator of food intake. Twit Text FOAVip Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite ????Am J Physiol Regul Integr Comp Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23576617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23576617 #FOAvip English Wikipedia <ref>{{Cite pmid|23576617 }}</ref> Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite #MMPMID23576617 Byerly MS ; Swanson RD ; Semsarzadeh NN ; McCulloh PS ; Kwon K ; Aja S ; Moran TH ; Wong GW ; Blackshaw S Am J Physiol Regul Integr Comp Physiol 2013[Jun]; 304 (12 ): R1085-95 PMID23576617 show ga Disruption of finely coordinated neuropeptide signals in the hypothalamus can result in altered food intake and body weight. We identified neuron-derived neurotrophic factor (NENF) as a novel secreted protein through a large-scale screen aimed at identifying novel secreted hypothalamic proteins that regulate food intake. We observed robust Nenf expression in hypothalamic nuclei known to regulate food intake, and its expression was altered under the diet-induced obese (DIO) condition relative to the fed state. Hypothalamic Nenf mRNA was regulated by brain-derived neurotrophic factor (BDNF) signaling, itself an important regulator of appetite. Delivery of purified recombinant BDNF into the lateral cerebral ventricle decreased hypothalamic Nenf expression, while pharmacological inhibition of trkB signaling increased Nenf mRNA expression. Furthermore, recombinant NENF administered via an intracerebroventricular cannula decreased food intake and body weight and increased hypothalamic Pomc and Mc4r mRNA expression. Importantly, the appetite-suppressing effect of NENF was abrogated in obese mice fed a high-fat diet, demonstrating a diet-dependent modulation of NENF function. We propose the existence of a regulatory circuit involving BDNF, NENF, and melanocortin signaling. Our study validates the power of using an integrated experimental and bioinformatic approach to identify novel CNS-derived proteins with appetite-modulating function and reveals NENF as an important central modulator of food intake. |Animals [MESH] |Appetite/drug effects/*physiology [MESH] |Brain-Derived Neurotrophic Factor/administration & dosage/pharmacology [MESH] |Diet, High-Fat/adverse effects [MESH] |Disease Models, Animal [MESH] |Energy Metabolism/drug effects/physiology [MESH] |Hypothalamus/*metabolism [MESH] |Injections, Intraventricular [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Nerve Tissue Proteins/administration & dosage/*metabolism/pharmacology [MESH] |Obesity/chemically induced/metabolism/*physiopathology [MESH] |Pro-Opiomelanocortin/metabolism [MESH] |Receptor, Melanocortin, Type 4/metabolism [MESH] |Recombinant Proteins/administration & dosage/pharmacology [MESH]Identification of hypothalamic neuron-derived neurotrophic factor as a(epmc).pdf DeepDyve Pubget Overpricing