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10.1158/2159-8290.CD-13-0081 http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-13-0081 C3679355!3679355 !23535903     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23535903 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Discov 2013 ; 3 (6 ): 674-89 Nephropedia Template TP {{tp|p=23535903 |t=2013. Canonical Wnt/?-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance |pdf=|usr=}}{{23535903 }} gab.com Text Canonical Wnt/ -catenin signaling drives human schwann cell transformation, progression, and tumor maintenance JO: Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=23535903 #FOAvip Genetic changes required for the formation and progression of human Schwann cell tumors remain elusive. Using a Sleeping Beauty forward genetic screen, we identified several genes involved in canonical Wnt signaling as potential drivers of benign neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs). In human neurofibromas and MPNSTs, activation of Wnt signaling increased with tumor grade and was associated with downregulation of ?-catenin destruction complex members or overexpression of a ligand that potentiates Wnt signaling, R-spondin 2 (RSPO2). Induction of Wnt signaling was sufficient to induce transformed properties in immortalized human Schwann cells, and downregulation of this pathway was sufficient to reduce the tumorigenic phenotype of human MPNST cell lines. Small-molecule inhibition of Wnt signaling effectively reduced the viability of MPNST cell lines and synergistically induced apoptosis when combined with an mTOR inhibitor, RAD-001, suggesting that Wnt inhibition represents a novel target for therapeutic intervention in Schwann cell tumors. Twit Text FOAVip Canonical Wnt/ -catenin signaling drives human schwann cell transformation, progression, and tumor maintenance ????Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=23535903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23535903 #FOAvip English Wikipedia <ref>{{Cite pmid|23535903 }}</ref> Canonical Wnt/?-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance #MMPMID23535903 Watson AL ; Rahrmann EP ; Moriarity BS ; Choi K ; Conboy CB ; Greeley AD ; Halfond AL ; Anderson LK ; Wahl BR ; Keng VW ; Rizzardi AE ; Forster CL ; Collins MH ; Sarver AL ; Wallace MR ; Schmechel SC ; Ratner N ; Largaespada DA Cancer Discov 2013[Jun]; 3 (6 ): 674-89 PMID23535903 show ga Genetic changes required for the formation and progression of human Schwann cell tumors remain elusive. Using a Sleeping Beauty forward genetic screen, we identified several genes involved in canonical Wnt signaling as potential drivers of benign neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs). In human neurofibromas and MPNSTs, activation of Wnt signaling increased with tumor grade and was associated with downregulation of ?-catenin destruction complex members or overexpression of a ligand that potentiates Wnt signaling, R-spondin 2 (RSPO2). Induction of Wnt signaling was sufficient to induce transformed properties in immortalized human Schwann cells, and downregulation of this pathway was sufficient to reduce the tumorigenic phenotype of human MPNST cell lines. Small-molecule inhibition of Wnt signaling effectively reduced the viability of MPNST cell lines and synergistically induced apoptosis when combined with an mTOR inhibitor, RAD-001, suggesting that Wnt inhibition represents a novel target for therapeutic intervention in Schwann cell tumors. |*Wnt Signaling Pathway [MESH] |Animals [MESH] |Cell Growth Processes/physiology [MESH] |Cell Line, Tumor [MESH] |Cell Transformation, Neoplastic/genetics/*metabolism/pathology [MESH] |Disease Progression [MESH] |Down-Regulation [MESH] |Humans [MESH] |Mice [MESH] |Nerve Sheath Neoplasms/genetics/*metabolism/*pathology [MESH] |Schwann Cells/*metabolism/*pathology [MESH] |Xenograft Model Antitumor Assays [MESH]Canonical Wnt/?-catenin signaling drives human schwann cell transforma(epmc).pdf DeepDyve Pubget Overpricing