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2013 ; 31
(18
): 2265-72
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Use of ?-blockers, angiotensin-converting enzyme inhibitors, angiotensin II
receptor blockers, and risk of breast cancer recurrence: a Danish nationwide
prospective cohort study
#MMPMID23650417
Sørensen GV
; Ganz PA
; Cole SW
; Pedersen LA
; Sørensen HT
; Cronin-Fenton DP
; Garne JP
; Christiansen PM
; Lash TL
; Ahern TP
J Clin Oncol
2013[Jun]; 31
(18
): 2265-72
PMID23650417
show ga
PURPOSE: To estimate associations between use of ?-blockers,
angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blockers
(ARBs) and breast cancer recurrence in a large Danish cohort. PATIENTS AND
METHODS: We enrolled 18,733 women diagnosed with nonmetastatic breast cancer
between 1996 and 2003. Patient, treatment, and 10-year recurrence data were
ascertained from the Danish Breast Cancer Cooperative Group registry.
Prescription and medical histories were ascertained by linkage to the National
Prescription Registry and Registry of Patients, respectively. ?-Blocker exposure
was defined in aggregate and according to solubility, receptor selectivity, and
individual drugs. ACE inhibitor and ARB exposures were defined in aggregate.
Recurrence associations were estimated with multivariable Cox regression models
in which time-varying drug exposures were lagged by 1 year. RESULTS: Compared
with never users, users of any ?-blocker had a lower recurrence hazard in
unadjusted models (unadjusted hazard ratio [HR] = 0.91; 95% CI, 0.81 to 1.0) and
a slightly higher recurrence hazard in adjusted models (adjusted HR = 1.3; 95%
CI, 1.1 to 1.5). Associations were similar for exposures defined by receptor
selectivity and solubility. Although most individual ?-blockers showed no
association with recurrence, metoprolol and sotalol were associated with
increased recurrence rates (adjusted metoprolol HR = 1.5, 95% CI, 1.2 to 1.8;
adjusted sotalol HR = 2.0, 95% CI, 0.99 to 4.0). ACE inhibitors were associated
with a slightly increased recurrence hazard, whereas ARBs were not associated
with recurrence (adjusted ACE inhibitor HR = 1.2, 95% CI, 0.97 to 1.4; adjusted
ARBs HR = 1.1, 95% CI, 0.85 to 1.3). CONCLUSION: Our data do not support the
hypothesis that ?-blockers attenuate breast cancer recurrence risk.
|Adrenergic beta-Antagonists/*adverse effects/therapeutic use
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Angiotensin Receptor Antagonists/*adverse effects/therapeutic use
[MESH]
|Angiotensin-Converting Enzyme Inhibitors/*adverse effects/therapeutic use
[MESH]