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10.1038/jcbfm.2013.35 http://scihub22266oqcxt.onion/10.1038/jcbfm.2013.35 C3677116!3677116!23462572     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cereb+Blood+Flow+Metab 2013 ; 33 (6): 944-53 Nephropedia Template TP {{tp|p=23462572|t=2013. Detrimental effects of leptin on intracerebral hemorrhage via the STAT3 signal pathway |pdf=|usr=}}{{23462572}} gab.com Text Detrimental effects of leptin on intracerebral hemorrhage via the STAT3 signal pathway JO: J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=23462572 #FOAvip Leptin, one of the most important adipokines, is not only an energy regulator but also a regulator of innate immunity. Inflammation plays a key role in the tissue damage after intracerebral hemorrhage (ICH), and we sought to investigate whether leptin has a detrimental effect on ICH. After the injection of a high replacement dose (0.04?mg/kg) and two pharmacologic doses (4 and 8?mg/kg) of leptin, brain water contents increased significantly compared with that of control mice (P<0.05), which was confirmed when comparing the results with leptin-deficient ob/ob and wild-type (WT) mice (78.8%±0.6% versus 79.7%±0.6%, P<0.05). The number of Ox6-positive microglia/macrophages was increased in the leptin-injected group and decreased in ob/ob compared with WT mice. Among the candidate signal transducers, an increase in signal transduction and activator of transcription 3 (STAT3) levels was found after leptin injection. When we administered NSC74859, a specific inhibitor of phosphorylated STAT3 (pSTAT3), the water content became normalized. Activity of pSTAT3 was found mainly in Ox6-positive microglia/macrophages, but not in either neurons or astrocytes. We demonstrate that leptin plays a critical role in the secondary brain injury around a hematoma and is a novel mediator of the inflammation. This detrimental effect of leptin on ICH is mediated by the STAT3 signaling pathway in inflammatory cells. Twit Text FOAVip Detrimental effects of leptin on intracerebral hemorrhage via the STAT3 signal pathway ????J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=23462572 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23462572 #FOAvip English Wikipedia <ref>{{Cite pmid|23462572}}</ref> Detrimental effects of leptin on intracerebral hemorrhage via the STAT3 signal pathway #MMPMID23462572 Kim CK; Ryu WS; Choi IY; Kim YJ; Rim D; Kim BJ; Jang H; Yoon BW; Lee SH J Cereb Blood Flow Metab 2013[Jun]; 33 (6): 944-53 PMID23462572show ga Leptin, one of the most important adipokines, is not only an energy regulator but also a regulator of innate immunity. Inflammation plays a key role in the tissue damage after intracerebral hemorrhage (ICH), and we sought to investigate whether leptin has a detrimental effect on ICH. After the injection of a high replacement dose (0.04?mg/kg) and two pharmacologic doses (4 and 8?mg/kg) of leptin, brain water contents increased significantly compared with that of control mice (P<0.05), which was confirmed when comparing the results with leptin-deficient ob/ob and wild-type (WT) mice (78.8%±0.6% versus 79.7%±0.6%, P<0.05). The number of Ox6-positive microglia/macrophages was increased in the leptin-injected group and decreased in ob/ob compared with WT mice. Among the candidate signal transducers, an increase in signal transduction and activator of transcription 3 (STAT3) levels was found after leptin injection. When we administered NSC74859, a specific inhibitor of phosphorylated STAT3 (pSTAT3), the water content became normalized. Activity of pSTAT3 was found mainly in Ox6-positive microglia/macrophages, but not in either neurons or astrocytes. We demonstrate that leptin plays a critical role in the secondary brain injury around a hematoma and is a novel mediator of the inflammation. This detrimental effect of leptin on ICH is mediated by the STAT3 signaling pathway in inflammatory cells. äDetrimental effects of leptin on intracerebral hemorrhage via the STAT(epmc).pdf DeepDyve Pubget Overpricing