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10.1089/wound.2012.0419 http://scihub22266oqcxt.onion/10.1089/wound.2012.0419 C3676658!3676658!24761336     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Wound+Care+(New+Rochelle) 2013 ; 2 (5): 225-37 Nephropedia Template TP {{tp|p=24761336|t=2013. Transforming Growth Factor Beta Signaling in Cutaneous Wound Healing: Lessons Learned from Animal Studies |pdf=|usr=}}{{24761336}} gab.com Text Transforming Growth Factor Beta Signaling in Cutaneous Wound Healing: Lessons Learned from Animal Studies JO: Adv Wound Care (New Rochelle) http://www.kidney.de/pget.php?&tw=1&pmid=24761336 #FOAvip Significance: Wound healing is a complex physiological process involving a multitude of growth factors, among which transforming growth factor beta (TGF-?) has the broadest spectrum of effects. Animal studies have provided key information on the mechanisms of TGF-? action in wound healing and have guided the development of therapeutic strategies targeting the TGF-? pathway to improve wound healing and scarring outcome. Recent Advances: Development of tissue-specific expression systems for overexpression or knockout of TGF-? signaling pathway components has led to novel insight into the role of TGF-? signaling in wound healing. This work has also identified molecules that might serve as molecular targets for the treatment of pathological skin conditions such as chronic wounds and excessive scarring (fibrosis). Critical Issues: Many of the mouse models with genetic alterations in the TGF-? signaling pathway develop an underlying skin abnormality, which may pose some limitations on the interpretation of wound-healing results obtained in these animals. Also, TGF-?'s pleiotropic effects on many cell types throughout all phases of wound healing present a challenge in designing specific strategies for targeting the TGF-? signaling pathway to promote wound healing or reduce scarring. Future Directions: Further characterization of TGF-? signaling pathway components using inducible tissue-specific overexpression or knockout technology will be needed to corroborate results obtained in mouse models that display a skin phenotype, and to better understand the role of TGF-? signaling during distinct phases of the wound-healing process. Such studies will also provide a better understanding of how TGF-? mediates its autocrine, paracrine, and double paracrine effects on cellular responses in vivo during wound healing. Twit Text FOAVip Transforming Growth Factor Beta Signaling in Cutaneous Wound Healing: Lessons Learned from Animal Studies ????Adv Wound Care (New Rochelle) http://www.kidney.de/pget.php?&tw=1&pmid=24761336 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24761336 #FOAvip English Wikipedia <ref>{{Cite pmid|24761336}}</ref> Transforming Growth Factor Beta Signaling in Cutaneous Wound Healing: Lessons Learned from Animal Studies #MMPMID24761336 Finnson KW; Arany PR; Philip A Adv Wound Care (New Rochelle) 2013[Jun]; 2 (5): 225-37 PMID24761336show ga Significance: Wound healing is a complex physiological process involving a multitude of growth factors, among which transforming growth factor beta (TGF-?) has the broadest spectrum of effects. Animal studies have provided key information on the mechanisms of TGF-? action in wound healing and have guided the development of therapeutic strategies targeting the TGF-? pathway to improve wound healing and scarring outcome. Recent Advances: Development of tissue-specific expression systems for overexpression or knockout of TGF-? signaling pathway components has led to novel insight into the role of TGF-? signaling in wound healing. This work has also identified molecules that might serve as molecular targets for the treatment of pathological skin conditions such as chronic wounds and excessive scarring (fibrosis). Critical Issues: Many of the mouse models with genetic alterations in the TGF-? signaling pathway develop an underlying skin abnormality, which may pose some limitations on the interpretation of wound-healing results obtained in these animals. Also, TGF-?'s pleiotropic effects on many cell types throughout all phases of wound healing present a challenge in designing specific strategies for targeting the TGF-? signaling pathway to promote wound healing or reduce scarring. Future Directions: Further characterization of TGF-? signaling pathway components using inducible tissue-specific overexpression or knockout technology will be needed to corroborate results obtained in mouse models that display a skin phenotype, and to better understand the role of TGF-? signaling during distinct phases of the wound-healing process. Such studies will also provide a better understanding of how TGF-? mediates its autocrine, paracrine, and double paracrine effects on cellular responses in vivo during wound healing. äTransforming Growth Factor Beta Signaling in Cutaneous Wound Healing: (epmc).pdf DeepDyve Pubget Overpricing