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10.1007/s00586-013-2715-7 http://scihub22266oqcxt.onion/10.1007/s00586-013-2715-7 C3676549!3676549!23455951     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Spine+J 2013 ; 22 (6): 1417-22 Nephropedia Template TP {{tp|p=23455951|t=2013. Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts |pdf=|usr=}}{{23455951}} gab.com Text Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts JO: Eur Spine J http://www.kidney.de/pget.php?&tw=1&pmid=23455951 #FOAvip Introduction: Aneurysmal bone cysts (ABCs) are expansive and destructive lesions positive for osteoclast markers, resembling benign giant cell tumors (GCTs). Treatment options include surgical resection, curettage and cavity filling, embolization, injection of fibrosing agents, or radiotherapy. Particularly in children and adolescents with spinal ABCs, these options may be unsatisfactory, and innovative forms of treatment are needed. Denosumab is a human monoclonal antibody that inhibits osteoclast function by blocking the cytokine receptor activator of the nuclear factor-kappa B ligand. Satisfactory results with denosumab in treating GCTs and immunohistochemical similarities suggest that it may also have positive effects on ABCs. Methods and Results: This report is the first description of the therapeutic use of denosumab in two patients with spinal ABCs. Two boys (aged 8 and 11) had recurrent ABCs at C5 after surgery with intralesional tumor resection. Treatment options were discussed by the interdisciplinary tumor board. Arterial embolization was attempted, but failed due to an absence of appropriate afferent arteries. After the families had received extensive information and provided written consent, denosumab therapy was initiated as an individualized treatment, despite the absence as yet of scientific evidence. After the start of denosumab therapy, both patients recovered from pain and neurologic symptoms significantly and are now in a healthy condition with no severe side effects. Magnetic resonance imaging check-ups after 2 or 4 months of denosumab treatment, respectively, showed tumor regression in both patients. Discussion: Longer follow-up and clinical studies are warranted to establish the value of denosumab in the treatment of ABCs. Twit Text FOAVip Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts ????Eur Spine J http://www.kidney.de/pget.php?&tw=1&pmid=23455951 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23455951 #FOAvip English Wikipedia <ref>{{Cite pmid|23455951}}</ref> Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts #MMPMID23455951 Lange T; Stehling C; Fröhlich B; Klingenhöfer M; Kunkel P; Schneppenheim R; Escherich G; Gosheger G; Hardes J; Jürgens H; Schulte TL Eur Spine J 2013[Jun]; 22 (6): 1417-22 PMID23455951show ga Introduction: Aneurysmal bone cysts (ABCs) are expansive and destructive lesions positive for osteoclast markers, resembling benign giant cell tumors (GCTs). Treatment options include surgical resection, curettage and cavity filling, embolization, injection of fibrosing agents, or radiotherapy. Particularly in children and adolescents with spinal ABCs, these options may be unsatisfactory, and innovative forms of treatment are needed. Denosumab is a human monoclonal antibody that inhibits osteoclast function by blocking the cytokine receptor activator of the nuclear factor-kappa B ligand. Satisfactory results with denosumab in treating GCTs and immunohistochemical similarities suggest that it may also have positive effects on ABCs. Methods and Results: This report is the first description of the therapeutic use of denosumab in two patients with spinal ABCs. Two boys (aged 8 and 11) had recurrent ABCs at C5 after surgery with intralesional tumor resection. Treatment options were discussed by the interdisciplinary tumor board. Arterial embolization was attempted, but failed due to an absence of appropriate afferent arteries. After the families had received extensive information and provided written consent, denosumab therapy was initiated as an individualized treatment, despite the absence as yet of scientific evidence. After the start of denosumab therapy, both patients recovered from pain and neurologic symptoms significantly and are now in a healthy condition with no severe side effects. Magnetic resonance imaging check-ups after 2 or 4 months of denosumab treatment, respectively, showed tumor regression in both patients. Discussion: Longer follow-up and clinical studies are warranted to establish the value of denosumab in the treatment of ABCs. äDenosumab: a potential new and innovative treatment option for aneurys(epmc).pdf DeepDyve Pubget Overpricing