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10.1074/jbc.M112.411272

http://scihub22266oqcxt.onion/10.1074/jbc.M112.411272
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C3675634!3675634!23625915
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suck abstract from ncbi


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pmid23625915      J+Biol+Chem 2013 ; 288 (23): 17030-41
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  • Store-operated Ca2+ Entry (SOCE) Induced by Protease-activated Receptor-1 Mediates STIM1 Protein Phosphorylation to Inhibit SOCE in Endothelial Cells through AMP-activated Protein Kinase and p38? Mitogen-activated Protein Kinase* #MMPMID23625915
  • Sundivakkam PC; Natarajan V; Malik AB; Tiruppathi C
  • J Biol Chem 2013[Jun]; 288 (23): 17030-41 PMID23625915show ga
  • Background: STIM1 is essential for store-operated Ca2+ entry (SOCE) in endothelial cells.Results: SOCE-activated AMPK?1-p38? signaling phosphorylates STIM1, which in turn inhibits SOCE in endothelial cells.Conclusion: SOCE-activated signaling pathway completes a negative feedback loop to regulate SOCE in endothelial cells.Significance: Selective p38? agonists may represent potential therapeutic agents to reverse the vascular leak syndrome.
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