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10.1074/jbc.M112.446633

http://scihub22266oqcxt.onion/10.1074/jbc.M112.446633
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C3675609!3675609!23589286
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suck abstract from ncbi


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pmid23589286      J+Biol+Chem 2013 ; 288 (23): 16761-74
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  • Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells: IMPLICATIONS IN INTERVERTEBRAL DISC DEGENERATION* #MMPMID23589286
  • Wang H; Tian Y; Wang J; Phillips KLE; Binch ALA; Dunn S; Cross A; Chiverton N; Zheng Z; Shapiro IM; Le Maitre CL; Risbud MV
  • J Biol Chem 2013[Jun]; 288 (23): 16761-74 PMID23589286show ga
  • Background: The regulation of NOTCH signaling under inflammatory conditions in the nucleus pulposus is unknown.Results: Expression of select NOTCH pathway genes, including NOTCH2 and NOTCH signaling, is regulated by IL-1? and TNF-?.Conclusion: Inflammatory cytokines promote NOTCH signaling in disc.Significance: NOTCH signaling may play a role in pathogenesis of disc disease.
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