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10.1074/jbc.M113.468728

http://scihub22266oqcxt.onion/10.1074/jbc.M113.468728
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C3675597!3675597!23609443
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suck abstract from ncbi


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pmid23609443      J+Biol+Chem 2013 ; 288 (23): 16619-28
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  • Stabilization of the Conductive Conformation of a Voltage-gated K+ (Kv) Channel: THE LID MECHANISM* #MMPMID23609443
  • Santos JS; Syeda R; Montal M
  • J Biol Chem 2013[Jun]; 288 (23): 16619-28 PMID23609443show ga
  • Background: In voltage-gated K+ channels, sensor and pore are two structural modules, but their functional coupling remains elusive.Results: Premature pore closing is bypassed by association of the filter gate with novel open conformation stabilizers.Conclusion: Prolonged occupancy of cargo at the gate underlies stabilization.Significance: A gate covered by a lid provides new ways of thinking about gating mechanisms.
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