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10.1074/jbc.M112.435545

http://scihub22266oqcxt.onion/10.1074/jbc.M112.435545
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C3675564!3675564!23612963
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suck abstract from ncbi


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pmid23612963      J+Biol+Chem 2013 ; 288 (23): 16247-61
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  • Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling* #MMPMID23612963
  • Chen W; Zhou Z; Li L; Zhong CQ; Zheng X; Wu X; Zhang Y; Ma H; Huang D; Li W; Xia Z; Han J
  • J Biol Chem 2013[Jun]; 288 (23): 16247-61 PMID23612963show ga
  • Background: Receptor interacting protein 3 (RIP3)-mixed lineage kinase domain-like (MLKL) interaction is essential for necroptosis.Results: Murine RIP3 does not interact with human MLKL and vice versa due to sequence differences in and around the RIP3 phosphorylation sites.Conclusion: Different sequences in human and mouse RIP3 control the functionally conserved RIP3-MLKL interaction.Significance: This study provided new insights into the function of RIP3-MLKL interaction in necroptosis.
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