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10.1074/jbc.M113.454538 http://scihub22266oqcxt.onion/10.1074/jbc.M113.454538 C3675562!3675562 !23609450     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23609450 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2013 ; 288 (23 ): 16225-16234 Nephropedia Template TP {{tp|p=23609450 |t=2013. Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species |pdf=|usr=}}{{23609450 }} gab.com Text Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=23609450 #FOAvip Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate immunity with a more opportunistic infection. LPS-tolerized macrophages, which are re-challenged by LPS after prior exposure to LPS, are regarded as the common model of hypo-responsiveness for SAIS. However, the molecular mechanisms of endotoxin tolerance and SAIS remain to be fully elucidated. In addition, negative regulation of the Toll-like receptor (TLR)-triggered innate inflammatory response needs further investigation. Here we show that expression of immune responsive gene 1 (IRG1) was highly up-regulated in the peripheral blood mononuclear cells of septic patients and in LPS-tolerized mouse macrophages. IRG1 significantly suppressed TLR-triggered production of proinflammatory cytokines TNF-?, IL-6, and IFN-? in LPS-tolerized macrophages, with the elevated expression of reactive oxygen species (ROS) and A20. Moreover, ROS enhanced A20 expression by increasing the H3K4me3 modification of histone on the A20 promoter domain, and supplement of the ROS abrogated the IRG1 knockdown function in breaking endotoxin tolerance by increasing A20 expression. Our results demonstrate that inducible IRG1 promotes endotoxin tolerance by increasing A20 expression through ROS, indicating a new molecular mechanism regulating hypoinflammation of sepsis and endotoxin tolerance. Twit Text FOAVip Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=23609450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23609450 #FOAvip English Wikipedia <ref>{{Cite pmid|23609450 }}</ref> Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species #MMPMID23609450 Li Y ; Zhang P ; Wang C ; Han C ; Meng J ; Liu X ; Xu S ; Li N ; Wang Q ; Shi X ; Cao X J Biol Chem 2013[Jun]; 288 (23 ): 16225-16234 PMID23609450 show ga Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate immunity with a more opportunistic infection. LPS-tolerized macrophages, which are re-challenged by LPS after prior exposure to LPS, are regarded as the common model of hypo-responsiveness for SAIS. However, the molecular mechanisms of endotoxin tolerance and SAIS remain to be fully elucidated. In addition, negative regulation of the Toll-like receptor (TLR)-triggered innate inflammatory response needs further investigation. Here we show that expression of immune responsive gene 1 (IRG1) was highly up-regulated in the peripheral blood mononuclear cells of septic patients and in LPS-tolerized mouse macrophages. IRG1 significantly suppressed TLR-triggered production of proinflammatory cytokines TNF-?, IL-6, and IFN-? in LPS-tolerized macrophages, with the elevated expression of reactive oxygen species (ROS) and A20. Moreover, ROS enhanced A20 expression by increasing the H3K4me3 modification of histone on the A20 promoter domain, and supplement of the ROS abrogated the IRG1 knockdown function in breaking endotoxin tolerance by increasing A20 expression. Our results demonstrate that inducible IRG1 promotes endotoxin tolerance by increasing A20 expression through ROS, indicating a new molecular mechanism regulating hypoinflammation of sepsis and endotoxin tolerance. |Animals [MESH] |Carboxy-Lyases [MESH] |Cysteine Endopeptidases [MESH] |DNA-Binding Proteins/genetics/*immunology [MESH] |Female [MESH] |Gene Expression Regulation/*drug effects/genetics/immunology [MESH] |Gene Knockdown Techniques [MESH] |Histones/genetics/immunology [MESH] |Humans [MESH] |Hydro-Lyases/genetics/*immunology [MESH] |Immune Tolerance/*drug effects [MESH] |Immunity, Innate/*drug effects [MESH] |Interferon-beta/genetics/immunology [MESH] |Interleukin-6/genetics/immunology [MESH] |Intracellular Signaling Peptides and Proteins/genetics/*immunology [MESH] |Lipopolysaccharides/immunology/*toxicity [MESH] |Macrophages/*immunology/pathology [MESH] |Male [MESH] |Mice [MESH] |Monocytes/immunology/pathology [MESH] |Nuclear Proteins/genetics/*immunology [MESH] |Proteins/genetics/*immunology [MESH] |Reactive Oxygen Species/*immunology [MESH] |Sepsis/genetics/*immunology/pathology [MESH] |Tumor Necrosis Factor alpha-Induced Protein 3 [MESH] |Tumor Necrosis Factor-alpha/genetics/immunology [MESH]Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increa(epmc).pdf DeepDyve Pubget Overpricing