The FBW7-KLF2 axis regulates endothelial functions #MMPMID23567558
Zhao Y; Sun Y
Cell Res 2013[Jun]; 23 (6): 741-3 PMID23567558show ga
FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.