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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Bioinformatics 2013 ; 29 (12): 1485-7 Nephropedia Template TP
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Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index #MMPMID23047559
Paredes SH; Melgar MF; Sethupathy P
Bioinformatics 2013[Jun]; 29 (12): 1485-7 PMID23047559show ga
Motivation: It has been known for more than 2 decades that after RNA polymerase II (RNAPII) initiates transcription, it can enter into a paused or stalled state immediately downstream of the transcription start site before productive elongation. Recent advances in high-throughput genomic technologies facilitated the discovery that RNAPII pausing at promoters is a widespread physiologically regulated phenomenon. The molecular underpinnings of pausing are incompletely understood. The CCCTC-factor (CTCF) is a ubiquitous nuclear factor that has diverse regulatory functions, including a recently discovered role in promoting RNAPII pausing at splice sites.Results: In this study, we analyzed CTCF binding sites and nascent transcriptomic data from three different cell types, and found that promoter-proximal CTCF binding is significantly associated with RNAPII pausing.Contact:praveen_sethupathy@med.unc.eduSupplementary information:Supplementary data are available at Bioinformatics online.