Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23047559
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Bioinformatics
2013 ; 29
(12
): 1485-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Promoter-proximal CCCTC-factor binding is associated with an increase in the
transcriptional pausing index
#MMPMID23047559
Paredes SH
; Melgar MF
; Sethupathy P
Bioinformatics
2013[Jun]; 29
(12
): 1485-7
PMID23047559
show ga
MOTIVATION: It has been known for more than 2 decades that after RNA polymerase
II (RNAPII) initiates transcription, it can enter into a paused or stalled state
immediately downstream of the transcription start site before productive
elongation. Recent advances in high-throughput genomic technologies facilitated
the discovery that RNAPII pausing at promoters is a widespread physiologically
regulated phenomenon. The molecular underpinnings of pausing are incompletely
understood. The CCCTC-factor (CTCF) is a ubiquitous nuclear factor that has
diverse regulatory functions, including a recently discovered role in promoting
RNAPII pausing at splice sites. RESULTS: In this study, we analyzed CTCF binding
sites and nascent transcriptomic data from three different cell types, and found
that promoter-proximal CTCF binding is significantly associated with RNAPII
pausing.