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10.1093/bioinformatics/bts596 http://scihub22266oqcxt.onion/10.1093/bioinformatics/bts596 C3673211!3673211 !23047559     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23047559 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Bioinformatics 2013 ; 29 (12 ): 1485-7 Nephropedia Template TP {{tp|p=23047559 |t=2013. Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index |pdf=|usr=}}{{23047559 }} gab.com Text Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index JO: Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=23047559 #FOAvip MOTIVATION: It has been known for more than 2 decades that after RNA polymerase II (RNAPII) initiates transcription, it can enter into a paused or stalled state immediately downstream of the transcription start site before productive elongation. Recent advances in high-throughput genomic technologies facilitated the discovery that RNAPII pausing at promoters is a widespread physiologically regulated phenomenon. The molecular underpinnings of pausing are incompletely understood. The CCCTC-factor (CTCF) is a ubiquitous nuclear factor that has diverse regulatory functions, including a recently discovered role in promoting RNAPII pausing at splice sites. RESULTS: In this study, we analyzed CTCF binding sites and nascent transcriptomic data from three different cell types, and found that promoter-proximal CTCF binding is significantly associated with RNAPII pausing. Twit Text FOAVip Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index ????Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=23047559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23047559 #FOAvip English Wikipedia <ref>{{Cite pmid|23047559 }}</ref> Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index #MMPMID23047559 Paredes SH ; Melgar MF ; Sethupathy P Bioinformatics 2013[Jun]; 29 (12 ): 1485-7 PMID23047559 show ga MOTIVATION: It has been known for more than 2 decades that after RNA polymerase II (RNAPII) initiates transcription, it can enter into a paused or stalled state immediately downstream of the transcription start site before productive elongation. Recent advances in high-throughput genomic technologies facilitated the discovery that RNAPII pausing at promoters is a widespread physiologically regulated phenomenon. The molecular underpinnings of pausing are incompletely understood. The CCCTC-factor (CTCF) is a ubiquitous nuclear factor that has diverse regulatory functions, including a recently discovered role in promoting RNAPII pausing at splice sites. RESULTS: In this study, we analyzed CTCF binding sites and nascent transcriptomic data from three different cell types, and found that promoter-proximal CTCF binding is significantly associated with RNAPII pausing. |*Promoter Regions, Genetic [MESH] |*Transcription, Genetic [MESH] |Animals [MESH] |Binding Sites [MESH] |CCCTC-Binding Factor [MESH] |Cell Line [MESH] |Cells, Cultured [MESH] |Humans [MESH] |Mice [MESH] |RNA Polymerase II/*metabolism [MESH]Promoter-proximal CCCTC-factor binding is associated with an increase (epmc).pdf DeepDyve Pubget Overpricing