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10.4161/auto.24374 http://scihub22266oqcxt.onion/10.4161/auto.24374 C3672305!3672305!23548947     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2013 ; 9 (6): 931-2 Nephropedia Template TP {{tp|p=23548947|t=2013. Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance |pdf=|usr=}}{{23548947}} gab.com Text Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=23548947 #FOAvip During development in the thymus, each T lymphocyte is equipped with one, essentially unique, T cell receptor (TCR)-specificity. Due to its random nature, this process inevitably also leads to the emergence of potentially dangerous T lymphocytes that may recognize ?self.? Nevertheless, autoimmune tissue destruction, the cause of diseases such as multiple sclerosis and diabetes, is the exception rather than the rule. This state of immunological self-tolerance is to a large degree based upon a process called ?negative selection?: prior to joining the circulating lymphocyte pool, immature T cells test their receptor on self-antigens within the thymic microenvironment, and TCR engagement at this immature stage elicits an apoptotic suicide program. We now find evidence that macroautophagy supports the tolerogenic presentation of self-antigens in the thymus. Twit Text FOAVip Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=23548947 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23548947 #FOAvip English Wikipedia <ref>{{Cite pmid|23548947}}</ref> Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance #MMPMID23548947 Wu C; Aichinger M; Nedjic J; Klein L Autophagy 2013[Jun]; 9 (6): 931-2 PMID23548947show ga During development in the thymus, each T lymphocyte is equipped with one, essentially unique, T cell receptor (TCR)-specificity. Due to its random nature, this process inevitably also leads to the emergence of potentially dangerous T lymphocytes that may recognize ?self.? Nevertheless, autoimmune tissue destruction, the cause of diseases such as multiple sclerosis and diabetes, is the exception rather than the rule. This state of immunological self-tolerance is to a large degree based upon a process called ?negative selection?: prior to joining the circulating lymphocyte pool, immature T cells test their receptor on self-antigens within the thymic microenvironment, and TCR engagement at this immature stage elicits an apoptotic suicide program. We now find evidence that macroautophagy supports the tolerogenic presentation of self-antigens in the thymus. äThymic epithelial cells use macroautophagy to turn their inside out fo(epmc).pdf DeepDyve Pubget Overpricing