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10.4049/jimmunol.1300199 http://scihub22266oqcxt.onion/10.4049/jimmunol.1300199 C3668701!3668701!23645881     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2013 ; 190 (11): 5506-15 Nephropedia Template TP {{tp|p=23645881|t=2013. Regulation of the expression of GARP/latent-TGF-?1 complexes on mouse T cells and their role in Regulatory T Cell and Th17 differentiation1 |pdf=|usr=}}{{23645881}} gab.com Text Regulation of the expression of GARP/latent-TGF- 1 complexes on mouse T cells and their role in Regulatory T Cell and Th17 differentiation1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23645881 #FOAvip GARP/LRRC32 has previously been defined as a marker of activated human regulatory T-cells (Tregs) that is responsible for surface localization of latent TGF-?1. We find that GARP and latent TGF-?1 are also found on mouse Tregs activated via TCR stimulation, but in contrast to human Tregs, GARP is also expressed at a low level on resting Tregs. The expression of GARP can be upregulated on mouse Tregs by IL-2 or IL-4 exposure in the absence of TCR signaling. GARP is expressed at a low level on Tregs within the thymus and Treg precursors from the thymus concomitantly express GARP and Foxp3 upon exposure to IL-2. The expression of GARP is independent of TGF-?1 and TGF-?1 loading into GARP and is independent of furin-mediated processing of pro-TGF-?1 to latent TGF-?1. Specific deletion of GARP in CD4+ T cells results in lack of expression of latent-TGF-?1 on activated Tregs. GARP-deficient Tregs develop normally, are present in normal numbers in peripheral tissues, and are fully competent suppressors of the activation of T conventional cells in vitro. Activated Tregs expressing GARP/latent-TGF-?1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. Induction of both Th17 producing cells and Treg is preferentially induced by Tregs expressing the latent-TGF-?1/GARP complex on their cell surface rather than by secreted latent-TGF-?1. Twit Text FOAVip Regulation of the expression of GARP/latent-TGF- 1 complexes on mouse T cells and their role in Regulatory T Cell and Th17 differentiation1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23645881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23645881 #FOAvip English Wikipedia <ref>{{Cite pmid|23645881}}</ref> Regulation of the expression of GARP/latent-TGF-?1 complexes on mouse T cells and their role in Regulatory T Cell and Th17 differentiation1 #MMPMID23645881 Edwards JP; Fujii H; Zhou AX; Creemers J; Unutmaz D; Shevach EM J Immunol 2013[Jun]; 190 (11): 5506-15 PMID23645881show ga GARP/LRRC32 has previously been defined as a marker of activated human regulatory T-cells (Tregs) that is responsible for surface localization of latent TGF-?1. We find that GARP and latent TGF-?1 are also found on mouse Tregs activated via TCR stimulation, but in contrast to human Tregs, GARP is also expressed at a low level on resting Tregs. The expression of GARP can be upregulated on mouse Tregs by IL-2 or IL-4 exposure in the absence of TCR signaling. GARP is expressed at a low level on Tregs within the thymus and Treg precursors from the thymus concomitantly express GARP and Foxp3 upon exposure to IL-2. The expression of GARP is independent of TGF-?1 and TGF-?1 loading into GARP and is independent of furin-mediated processing of pro-TGF-?1 to latent TGF-?1. Specific deletion of GARP in CD4+ T cells results in lack of expression of latent-TGF-?1 on activated Tregs. GARP-deficient Tregs develop normally, are present in normal numbers in peripheral tissues, and are fully competent suppressors of the activation of T conventional cells in vitro. Activated Tregs expressing GARP/latent-TGF-?1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. Induction of both Th17 producing cells and Treg is preferentially induced by Tregs expressing the latent-TGF-?1/GARP complex on their cell surface rather than by secreted latent-TGF-?1. äRegulation of the expression of GARP/latent-TGF-?1 complexes on mouse (epmc).pdf DeepDyve Pubget Overpricing