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10.4049/jimmunol.1300199 http://scihub22266oqcxt.onion/10.4049/jimmunol.1300199 C3668701!3668701 !23645881     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23645881 &cmd=llinks): Failed to open stream: HTTP request failed! 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Regulation of the expression of GARP/latent TGF-?1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation |pdf=|usr=}}{{23645881 }} gab.com Text Regulation of the expression of GARP/latent TGF- 1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23645881 #FOAvip GARP/LRRC32 was defined as a marker of activated human regulatory T cells (Tregs) that is responsible for surface localization of latent TGF-?1. We find that GARP and latent TGF-?1 are also found on mouse Tregs activated via TCR stimulation; however, in contrast to human Tregs, GARP is also expressed at a low level on resting Tregs. The expression of GARP can be upregulated on mouse Tregs by IL-2 or IL-4 exposure in the absence of TCR signaling. GARP is expressed at a low level on Tregs within the thymus, and Treg precursors from the thymus concomitantly express GARP and Foxp3 upon exposure to IL-2. The expression of GARP is independent of TGF-?1 and TGF-?1 loading into GARP and is independent of furin-mediated processing of pro-TGF-?1 to latent TGF-?1. Specific deletion of GARP in CD4(+) T cells results in lack of expression of latent TGF-?1 on activated Tregs. GARP-deficient Tregs develop normally, are present in normal numbers in peripheral tissues, and are fully competent suppressors of the activation of conventional T cells in vitro. Activated Tregs expressing GARP/latent TGF-?1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. Induction of both Th17-producing cells and Tregs is caused preferentially by Tregs expressing the latent TGF-?1/GARP complex on their cell surface rather than by secreted latent TGF-?1. Twit Text FOAVip Regulation of the expression of GARP/latent TGF- 1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23645881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23645881 #FOAvip English Wikipedia <ref>{{Cite pmid|23645881 }}</ref> Regulation of the expression of GARP/latent TGF-?1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation #MMPMID23645881 Edwards JP ; Fujii H ; Zhou AX ; Creemers J ; Unutmaz D ; Shevach EM J Immunol 2013[Jun]; 190 (11 ): 5506-15 PMID23645881 show ga GARP/LRRC32 was defined as a marker of activated human regulatory T cells (Tregs) that is responsible for surface localization of latent TGF-?1. We find that GARP and latent TGF-?1 are also found on mouse Tregs activated via TCR stimulation; however, in contrast to human Tregs, GARP is also expressed at a low level on resting Tregs. The expression of GARP can be upregulated on mouse Tregs by IL-2 or IL-4 exposure in the absence of TCR signaling. GARP is expressed at a low level on Tregs within the thymus, and Treg precursors from the thymus concomitantly express GARP and Foxp3 upon exposure to IL-2. The expression of GARP is independent of TGF-?1 and TGF-?1 loading into GARP and is independent of furin-mediated processing of pro-TGF-?1 to latent TGF-?1. Specific deletion of GARP in CD4(+) T cells results in lack of expression of latent TGF-?1 on activated Tregs. GARP-deficient Tregs develop normally, are present in normal numbers in peripheral tissues, and are fully competent suppressors of the activation of conventional T cells in vitro. Activated Tregs expressing GARP/latent TGF-?1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. Induction of both Th17-producing cells and Tregs is caused preferentially by Tregs expressing the latent TGF-?1/GARP complex on their cell surface rather than by secreted latent TGF-?1. |*Cell Differentiation/genetics/immunology [MESH] |Animals [MESH] |Forkhead Transcription Factors/metabolism [MESH] |Furin/metabolism [MESH] |Gene Expression Regulation [MESH] |Latent TGF-beta Binding Proteins/genetics/*metabolism [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Mice [MESH] |Receptors, Antigen, T-Cell/metabolism [MESH] |T-Lymphocytes, Regulatory/*cytology/*metabolism [MESH] |Th17 Cells/*cytology/*metabolism [MESH] |Thymus Gland/immunology/metabolism [MESH]Regulation of the expression of GARP/latent TGF-?1 complexes on mouse (epmc).pdf DeepDyve Pubget Overpricing