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Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Autism+Res 2013 ; 6 (3): 212-20 Nephropedia Template TP
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Letting a typical mouse judge whether mouse social interactions are atypical #MMPMID23436806
Shah CR; Forsberg CG; Kang JQ; Veenstra-VanderWeele J
Autism Res 2013[Jun]; 6 (3): 212-20 PMID23436806show ga
LAY ABSTRACT: Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a ?typical? way. Quantitative or computerized assessment of social aptitude cannot substitute for this subjective judgment. We hypothesized that mice could be used to make a similar judgment if they prefer ?typical? over ?atypical? social interactions with mouse models relevant to ASD. We used typical C57BL/6 (B6) mice as ?judges? and evaluated their preference for a chamber containing a ?typical? or an ?atypical? mouse. For our atypical mice, we chose two strains with well-documented social phenotypes, as well a mutant line with abnormal social behavior and seizures. Overall, we observed a characteristic pattern of behavior over the course of 30 minutes, with the judges preferring the typical mouse chamber to the atypical mouse chamber during the last 10 minutes of the test. When we evaluated the individual stimulus pairings, two of the three showed a similar pattern as the overall results, and the other stimulus comparison showed a trend for a preference for the typical mouse chamber across the entire test. We repeated the experiments using the 129S6 strain of typical mice as judges and found a much less strong preference pattern across time. These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls. SCIENTIFIC ABSTRACT: Diagnosis of an autism spectrum disorder (ASD) requires a qualitative assessment of social aptitude: one person judging whether another person interacts in a ?typical? way. We hypothesized that mice could be used to make a similar judgment if they prefer ?typical? over ?atypical? social interactions with mouse models relevant to ASD. We used wildtype C57BL/6 (B6) mice as ?judges? and evaluated their preference for a chamber containing a ?typical? (B6 or 129S6) or an ?atypical? mouse. For our atypical mouse stimuli, we chose two inbred strains with well-documented social phenotypes (BTBR and BALB/c), as well a mutant line with abnormal social behavior and seizures (Gabrb3 +/?). Overall, we observed a stimulus by time interaction (P < 0.0001), with B6 mice preferring the typical mouse chamber during the last 10 minutes of the 30-minute test. For two of the individual stimulus pairings, we observed a similar chamber by time interaction (BALB/c vs. 129S6, P = 0.0007; Gabrb3 +/? vs. 129S6, P = 0.033). For the third stimulus pairing, we found a trend for preference of the typical mouse across time (BTBR vs. B6, P = 0.051). We repeated the experiments using 129S6 mice as judges and found a significant overall interaction (P = 0.034), but only one stimulus pairing reached significance on its own (BALB/c vs. 129S6, P = 0.0021). These data suggest that a characteristic pattern of exploration in B6 mice can distinguish some socially atypical animals from controls.
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Autism+Res 2013 ; 6 (3): 212-20
