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10.1016/j.bbagrm.2012.12.002 http://scihub22266oqcxt.onion/10.1016/j.bbagrm.2012.12.002 C3664190!3664190 !23246978     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23246978 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochim+Biophys+Acta 2013 ; 1829 (6-7 ): 680-8 Nephropedia Template TP {{tp|p=23246978 |t=2013. Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation |pdf=|usr=}}{{23246978 }} gab.com Text Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=23246978 #FOAvip AUF1 is a family of four proteins generated by alternative pre-mRNA splicing that form high affinity complexes with AU-rich, mRNA-destabilizing sequences located within the 3' untranslated regions of many labile mRNAs. While AUF1 binding is most frequently associated with accelerated mRNA decay, emerging examples have demonstrated roles as a mRNA stabilizer or even translational regulator for specific transcripts. In this review, we summarize recent advances in our understanding of mRNA recognition by AUF1 and the biochemical and functional consequences of these interactions. In addition, unique properties of individual AUF1 isoforms and the roles of these proteins in modulating expression of genes associated with inflammatory, neoplastic, and cardiac diseases are discussed. Finally, we describe mechanisms that regulate AUF1 expression in cells, and current knowledge of regulatory switches that modulate the cellular levels and/or activities of AUF1 isoforms through distinct protein post-translational modifications. This article is part of a Special Issue entitled: RNA Decay mechanisms. Twit Text FOAVip Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=23246978 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23246978 #FOAvip English Wikipedia <ref>{{Cite pmid|23246978 }}</ref> Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation #MMPMID23246978 White EJ ; Brewer G ; Wilson GM Biochim Biophys Acta 2013[Jun]; 1829 (6-7 ): 680-8 PMID23246978 show ga AUF1 is a family of four proteins generated by alternative pre-mRNA splicing that form high affinity complexes with AU-rich, mRNA-destabilizing sequences located within the 3' untranslated regions of many labile mRNAs. While AUF1 binding is most frequently associated with accelerated mRNA decay, emerging examples have demonstrated roles as a mRNA stabilizer or even translational regulator for specific transcripts. In this review, we summarize recent advances in our understanding of mRNA recognition by AUF1 and the biochemical and functional consequences of these interactions. In addition, unique properties of individual AUF1 isoforms and the roles of these proteins in modulating expression of genes associated with inflammatory, neoplastic, and cardiac diseases are discussed. Finally, we describe mechanisms that regulate AUF1 expression in cells, and current knowledge of regulatory switches that modulate the cellular levels and/or activities of AUF1 isoforms through distinct protein post-translational modifications. This article is part of a Special Issue entitled: RNA Decay mechanisms. |AU Rich Elements/*genetics [MESH] |Alternative Splicing/genetics [MESH] |Gene Expression Regulation [MESH] |Heterogeneous Nuclear Ribonucleoprotein D0 [MESH] |Heterogeneous-Nuclear Ribonucleoprotein D/*genetics [MESH] |Humans [MESH] |Protein Processing, Post-Translational [MESH] |RNA Precursors/genetics [MESH] |RNA Stability/*genetics [MESH]Post-transcriptional control of gene expression by AUF1: mechanisms, (epmc).pdf DeepDyve Pubget Overpricing