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10.1101/cshperspect.a013433 http://scihub22266oqcxt.onion/10.1101/cshperspect.a013433 C3662353!3662353 !23645855     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23645855 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cold+Spring+Harb+Perspect+Med 2013 ; 3 (6 ): ä Nephropedia Template TP {{tp|p=23645855 |t=2013. Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies |pdf=|usr=}}{{23645855 }} gab.com Text Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=23645855 #FOAvip Hemoglobin (Hb) has multiple pathophysiologic effects when released into the intravascular space during hemolysis. The extracellular effects of Hb have resulted in novel models of toxicity, which help to explain endothelial dysfunction and cardiovascular complications that accompany genetic hemolytic anemias, malaria, blood transfusion, and atherosclerosis. The majority of models focus on nitric oxide (NO) depletion; however, in local tissue environments, Hb can also act as a pro-oxidant and inflammatory agent. This can alter cellular differentiation with the potential to deviate immune responses. The understanding of these mechanisms set in the context of natural scavenger and detoxification systems may accelerate the development of novel treatment strategies. Twit Text FOAVip Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=23645855 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23645855 #FOAvip English Wikipedia <ref>{{Cite pmid|23645855 }}</ref> Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies #MMPMID23645855 Schaer DJ ; Buehler PW Cold Spring Harb Perspect Med 2013[Jun]; 3 (6 ): ä PMID23645855 show ga Hemoglobin (Hb) has multiple pathophysiologic effects when released into the intravascular space during hemolysis. The extracellular effects of Hb have resulted in novel models of toxicity, which help to explain endothelial dysfunction and cardiovascular complications that accompany genetic hemolytic anemias, malaria, blood transfusion, and atherosclerosis. The majority of models focus on nitric oxide (NO) depletion; however, in local tissue environments, Hb can also act as a pro-oxidant and inflammatory agent. This can alter cellular differentiation with the potential to deviate immune responses. The understanding of these mechanisms set in the context of natural scavenger and detoxification systems may accelerate the development of novel treatment strategies. |Anemia, Sickle Cell/blood/therapy [MESH] |Animals [MESH] |Antigens, CD/metabolism [MESH] |Antigens, Differentiation, Myelomonocytic/metabolism [MESH] |Atherosclerosis/blood [MESH] |CD163 Antigen [MESH] |Erythrocyte Transfusion [MESH] |Heme Oxygenase (Decyclizing)/metabolism [MESH] |Hemoglobins/*metabolism [MESH] |Hemolysis [MESH] |Hemopexin/metabolism [MESH] |Humans [MESH] |Hypertension, Pulmonary/physiopathology [MESH] |Malaria/blood [MESH] |Nitric Oxide/metabolism [MESH] |Oxidation-Reduction [MESH] |Receptors, Cell Surface/metabolism [MESH]Cell-free hemoglobin and its scavenger proteins: new disease models le(epmc).pdf DeepDyve Pubget Overpricing