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10.1101/cshperspect.a009993 http://scihub22266oqcxt.onion/10.1101/cshperspect.a009993 C3662349!3662349!23732852     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Med 2013 ; 3 (6): ä Nephropedia Template TP {{tp|p=23732852|t=2013. Genome Dynamics in Legionella: The Basis of Versatility and Adaptation to Intracellular Replication |pdf=|usr=}}{{23732852}} gab.com Text Genome Dynamics in Legionella: The Basis of Versatility and Adaptation to Intracellular Replication JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=23732852 #FOAvip Legionella pneumophila is a bacterial pathogen present in aquatic environments that can cause a severe pneumonia called Legionnaires? disease. Soon after its recognition, it was shown that Legionella replicates inside amoeba, suggesting that bacteria replicating in environmental protozoa are able to exploit conserved signaling pathways in human phagocytic cells. Comparative, evolutionary, and functional genomics suggests that the Legionella?amoeba interaction has shaped this pathogen more than previously thought. A complex evolutionary scenario involving mobile genetic elements, type IV secretion systems, and horizontal gene transfer among Legionella, amoeba, and other organisms seems to take place. This long-lasting coevolution led to the development of very sophisticated virulence strategies and a high level of temporal and spatial fine-tuning of bacteria host?cell interactions. We will discuss current knowledge of the evolution of virulence of Legionella from a genomics perspective and propose our vision of the emergence of this human pathogen from the environment. Twit Text FOAVip Genome Dynamics in Legionella: The Basis of Versatility and Adaptation to Intracellular Replication ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=23732852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23732852 #FOAvip English Wikipedia <ref>{{Cite pmid|23732852}}</ref> Genome Dynamics in Legionella: The Basis of Versatility and Adaptation to Intracellular Replication #MMPMID23732852 Gomez-Valero L; Buchrieser C Cold Spring Harb Perspect Med 2013[Jun]; 3 (6): ä PMID23732852show ga Legionella pneumophila is a bacterial pathogen present in aquatic environments that can cause a severe pneumonia called Legionnaires? disease. Soon after its recognition, it was shown that Legionella replicates inside amoeba, suggesting that bacteria replicating in environmental protozoa are able to exploit conserved signaling pathways in human phagocytic cells. Comparative, evolutionary, and functional genomics suggests that the Legionella?amoeba interaction has shaped this pathogen more than previously thought. A complex evolutionary scenario involving mobile genetic elements, type IV secretion systems, and horizontal gene transfer among Legionella, amoeba, and other organisms seems to take place. This long-lasting coevolution led to the development of very sophisticated virulence strategies and a high level of temporal and spatial fine-tuning of bacteria host?cell interactions. We will discuss current knowledge of the evolution of virulence of Legionella from a genomics perspective and propose our vision of the emergence of this human pathogen from the environment. äGenome Dynamics in Legionella: The Basis of Versatility and Adaptation(epmc).pdf DeepDyve Pubget Overpricing