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2013 ; 3
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gab.com Text
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English Wikipedia
Genome dynamics in Legionella: the basis of versatility and adaptation to
intracellular replication
#MMPMID23732852
Gomez-Valero L
; Buchrieser C
Cold Spring Harb Perspect Med
2013[Jun]; 3
(6
): ä PMID23732852
show ga
Legionella pneumophila is a bacterial pathogen present in aquatic environments
that can cause a severe pneumonia called Legionnaires' disease. Soon after its
recognition, it was shown that Legionella replicates inside amoeba, suggesting
that bacteria replicating in environmental protozoa are able to exploit conserved
signaling pathways in human phagocytic cells. Comparative, evolutionary, and
functional genomics suggests that the Legionella-amoeba interaction has shaped
this pathogen more than previously thought. A complex evolutionary scenario
involving mobile genetic elements, type IV secretion systems, and horizontal gene
transfer among Legionella, amoeba, and other organisms seems to take place. This
long-lasting coevolution led to the development of very sophisticated virulence
strategies and a high level of temporal and spatial fine-tuning of bacteria
host-cell interactions. We will discuss current knowledge of the evolution of
virulence of Legionella from a genomics perspective and propose our vision of the
emergence of this human pathogen from the environment.