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10.2337/db12-1345 http://scihub22266oqcxt.onion/10.2337/db12-1345 C3661622!3661622!23349491     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes 2013 ; 62 (6): 2072-7 Nephropedia Template TP {{tp|p=23349491|t=2013. Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes |pdf=|usr=}}{{23349491}} gab.com Text Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes JO: Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=23349491 #FOAvip Human type 1 diabetes (T1D) is an autoimmune disease associated with major histocompatibility complex polymorphisms, ?-cell autoantibodies, and autoreactive T cells. However, there is increasing evidence that innate cells may also play critical roles in T1D. We aimed to monitor peripheral immune cells in early stages of T1D (i.e., in healthy autoantibody-positive subjects) and in more advanced phases of the disease (i.e., at disease onset and years after diagnosis). We found a mild but significant and reproducible peripheral neutropenia that both precedes and accompanies the onset of T1D. This reduction was not due to peripheral neutrophil cell death, impaired differentiation, or the presence of anti-neutrophil antibodies. Neutrophils were observed by electron microscopy and immunohistochemical analysis in the exocrine pancreas of multiorgan donors with T1D (both at onset and at later stages of the disease) and not in that of multiorgan donors with type 2 diabetes or nondiabetic donors. These pancreas-infiltrating neutrophils mainly localized at the level of very small blood vessels. Our findings suggest the existence of a hitherto unrecognized clinical phenotype that might reflect unexplored pathogenic pathways underlying T1D. Twit Text FOAVip Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes ????Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=23349491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23349491 #FOAvip English Wikipedia <ref>{{Cite pmid|23349491}}</ref> Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes #MMPMID23349491 Valle A; Giamporcaro GM; Scavini M; Stabilini A; Grogan P; Bianconi E; Sebastiani G; Masini M; Maugeri N; Porretti L; Bonfanti R; Meschi F; De Pellegrin M; Lesma A; Rossini S; Piemonti L; Marchetti P; Dotta F; Bosi E; Battaglia M Diabetes 2013[Jun]; 62 (6): 2072-7 PMID23349491show ga Human type 1 diabetes (T1D) is an autoimmune disease associated with major histocompatibility complex polymorphisms, ?-cell autoantibodies, and autoreactive T cells. However, there is increasing evidence that innate cells may also play critical roles in T1D. We aimed to monitor peripheral immune cells in early stages of T1D (i.e., in healthy autoantibody-positive subjects) and in more advanced phases of the disease (i.e., at disease onset and years after diagnosis). We found a mild but significant and reproducible peripheral neutropenia that both precedes and accompanies the onset of T1D. This reduction was not due to peripheral neutrophil cell death, impaired differentiation, or the presence of anti-neutrophil antibodies. Neutrophils were observed by electron microscopy and immunohistochemical analysis in the exocrine pancreas of multiorgan donors with T1D (both at onset and at later stages of the disease) and not in that of multiorgan donors with type 2 diabetes or nondiabetic donors. These pancreas-infiltrating neutrophils mainly localized at the level of very small blood vessels. Our findings suggest the existence of a hitherto unrecognized clinical phenotype that might reflect unexplored pathogenic pathways underlying T1D. äReduction of Circulating Neutrophils Precedes and Accompanies Type 1 D(epmc).pdf DeepDyve Pubget Overpricing