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10.4049/jimmunol.1203569 http://scihub22266oqcxt.onion/10.4049/jimmunol.1203569 C3661195!3661195!23606541     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2013 ; 190 (11): 5454-8 Nephropedia Template TP {{tp|p=23606541|t=2013. Antigen-stimulated CD4 T cell expansion can be limited by their grazing of peptide-MHC complexes1 |pdf=|usr=}}{{23606541}} gab.com Text Antigen-stimulated CD4 T cell expansion can be limited by their grazing of peptide-MHC complexes1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23606541 #FOAvip It was recently shown that the expansion of CD4+ T cells during a primary immune reaction to a peptide from cytochrome c decreases approximately 0.5 log for every log increase in the number of cognate precursor cells, and that this remains valid over more than four orders of magnitude [Quiel, et al., Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number. PNAS, 2011, 108: 3312]. This observed ?power law? was explained by a mechanism where non-dividing mature T cells inhibit the proliferation of less-differentiated cells of the same specificity. Here we interpret the same data by a mechanism where CD4+ T cells acquire cognate peptide-MHC (pMHC) complexes from the surface of antigen presenting cells (APCs), thereby increasing the loss rate of pMHC. We show that a mathematical model implementing this ?T cell grazing" mechanism, and having a T cell proliferation rate that is determined by the concentration of pMHC, explains the data equally well. As a consequence, the data no longer unequivocally support the previous explanation, and the increased loss of pMHC complexes on APCs at high T cell densities is an equally valid interpretation of this striking data. Twit Text FOAVip Antigen-stimulated CD4 T cell expansion can be limited by their grazing of peptide-MHC complexes1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23606541 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23606541 #FOAvip English Wikipedia <ref>{{Cite pmid|23606541}}</ref> Antigen-stimulated CD4 T cell expansion can be limited by their grazing of peptide-MHC complexes1 #MMPMID23606541 De Boer RJ; Perelson AS J Immunol 2013[Jun]; 190 (11): 5454-8 PMID23606541show ga It was recently shown that the expansion of CD4+ T cells during a primary immune reaction to a peptide from cytochrome c decreases approximately 0.5 log for every log increase in the number of cognate precursor cells, and that this remains valid over more than four orders of magnitude [Quiel, et al., Antigen-stimulated CD4 T-cell expansion is inversely and log-linearly related to precursor number. PNAS, 2011, 108: 3312]. This observed ?power law? was explained by a mechanism where non-dividing mature T cells inhibit the proliferation of less-differentiated cells of the same specificity. Here we interpret the same data by a mechanism where CD4+ T cells acquire cognate peptide-MHC (pMHC) complexes from the surface of antigen presenting cells (APCs), thereby increasing the loss rate of pMHC. We show that a mathematical model implementing this ?T cell grazing" mechanism, and having a T cell proliferation rate that is determined by the concentration of pMHC, explains the data equally well. As a consequence, the data no longer unequivocally support the previous explanation, and the increased loss of pMHC complexes on APCs at high T cell densities is an equally valid interpretation of this striking data. äAntigen-stimulated CD4 T cell expansion can be limited by their grazin(epmc).pdf DeepDyve Pubget Overpricing