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10.1016/j.bbagrm.2013.03.002 http://scihub22266oqcxt.onion/10.1016/j.bbagrm.2013.03.002 C3660545!3660545!23500037     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2013 ; 1829 (ä): 624-33 Nephropedia Template TP {{tp|p=23500037|t=2013. Regulation of nonsense-mediated mRNA decay: Implications for physiology and disease |pdf=|usr=}}{{23500037}} gab.com Text Regulation of nonsense-mediated mRNA decay: Implications for physiology and disease JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=23500037 #FOAvip Nonsense-mediated mRNA decay (NMD) is an mRNA quality control mechanism that destabilizes aberrant mRNAs harboring premature termination (nonsense) codons (PTCs). Recent studies have shown that NMD also targets mRNAs transcribed from a large subset of wild-type genes. This raises the possibility that NMD itself is under regulatory control. Indeed, several recent studies have shown that NMD activity is modulated in specific cell types and that key components of the NMD pathway are regulated by several pathways, including microRNA circuits and NMD itself. Cellular stress also modulates the magnitude of NMD by mechanisms that are beginning to be understood. Here, we review the evidence that NMD is regulated and discuss the physiological role for this regulation. We propose that the efficiency of NMD is altered in some cellular contexts to regulate normal biological events. In disease states?such as in cancer?NMD is disturbed by intrinsic and extrinsic factors, resulting in altered levels of crucial NMD-targeted mRNAs that lead to downstream pathological consequences. Twit Text FOAVip Regulation of nonsense-mediated mRNA decay: Implications for physiology and disease ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=23500037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23500037 #FOAvip English Wikipedia <ref>{{Cite pmid|23500037}}</ref> Regulation of nonsense-mediated mRNA decay: Implications for physiology and disease #MMPMID23500037 Karam R; Wengrod J; Gardner LB; Wilkinson MF Biochim Biophys Acta 2013[Jun]; 1829 (ä): 624-33 PMID23500037show ga Nonsense-mediated mRNA decay (NMD) is an mRNA quality control mechanism that destabilizes aberrant mRNAs harboring premature termination (nonsense) codons (PTCs). Recent studies have shown that NMD also targets mRNAs transcribed from a large subset of wild-type genes. This raises the possibility that NMD itself is under regulatory control. Indeed, several recent studies have shown that NMD activity is modulated in specific cell types and that key components of the NMD pathway are regulated by several pathways, including microRNA circuits and NMD itself. Cellular stress also modulates the magnitude of NMD by mechanisms that are beginning to be understood. Here, we review the evidence that NMD is regulated and discuss the physiological role for this regulation. We propose that the efficiency of NMD is altered in some cellular contexts to regulate normal biological events. In disease states?such as in cancer?NMD is disturbed by intrinsic and extrinsic factors, resulting in altered levels of crucial NMD-targeted mRNAs that lead to downstream pathological consequences. äRegulation of nonsense-mediated mRNA decay: Implications for physiolog(epmc).pdf DeepDyve Pubget Overpricing