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10.4049/jimmunol.1202612 http://scihub22266oqcxt.onion/10.4049/jimmunol.1202612 C3660450!3660450!23630355     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2013 ; 190 (11): 5874-81 Nephropedia Template TP {{tp|p=23630355|t=2013. Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing |pdf=|usr=}}{{23630355}} gab.com Text Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23630355 #FOAvip Local failures following radiation therapy are multifactorial and the contributions of the tumor and the host are complex. Current models of tumor equilibrium suggest that a balance exists between cell birth and cell death due to insufficient angiogenesis, immune effects, or intrinsic cellular factors. We investigated whether host immune responses contribute to radiation induced tumor equilibrium in animal models. We report an essential role for immune cells and their cytokines in suppressing tumor cell regrowth in two experimental animal model systems. Depletion of T cells or neutralization of interferon-gamma reversed radiation-induced equilibrium leading to tumor regrowth. We also demonstrate that PD-L1 blockade augments T cell responses leading to rejection of tumors in radiation induced equilibrium. We identify an active interplay between tumor cells and immune cells that occurs in radiation-induced tumor equilibrium and suggest a potential role for disruption of the PD-L1/PD-1 axis in increasing local tumor control. Twit Text FOAVip Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23630355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23630355 #FOAvip English Wikipedia <ref>{{Cite pmid|23630355}}</ref> Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing #MMPMID23630355 Liang H; Deng L; Chmura S; Burnette B; Liadis N; Darga T; Beckett MA; Lingen MW; Witt M; Weichselbaum RR; Fu YX J Immunol 2013[Jun]; 190 (11): 5874-81 PMID23630355show ga Local failures following radiation therapy are multifactorial and the contributions of the tumor and the host are complex. Current models of tumor equilibrium suggest that a balance exists between cell birth and cell death due to insufficient angiogenesis, immune effects, or intrinsic cellular factors. We investigated whether host immune responses contribute to radiation induced tumor equilibrium in animal models. We report an essential role for immune cells and their cytokines in suppressing tumor cell regrowth in two experimental animal model systems. Depletion of T cells or neutralization of interferon-gamma reversed radiation-induced equilibrium leading to tumor regrowth. We also demonstrate that PD-L1 blockade augments T cell responses leading to rejection of tumors in radiation induced equilibrium. We identify an active interplay between tumor cells and immune cells that occurs in radiation-induced tumor equilibrium and suggest a potential role for disruption of the PD-L1/PD-1 axis in increasing local tumor control. äRadiation-induced equilibrium is a balance between tumor cell prolifer(epmc).pdf DeepDyve Pubget Overpricing