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10.4049/jimmunol.1202612 http://scihub22266oqcxt.onion/10.4049/jimmunol.1202612 C3660450!3660450 !23630355     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23630355 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol 2013 ; 190 (11 ): 5874-81 Nephropedia Template TP {{tp|p=23630355 |t=2013. Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing |pdf=|usr=}}{{23630355 }} gab.com Text Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23630355 #FOAvip Local failures following radiation therapy are multifactorial, and the contributions of the tumor and the host are complex. Current models of tumor equilibrium suggest that a balance exists between cell birth and cell death due to insufficient angiogenesis, immune effects, or intrinsic cellular factors. We investigated whether host immune responses contribute to radiation-induced tumor equilibrium in animal models. We report an essential role for immune cells and their cytokines in suppressing tumor cell regrowth in two experimental animal model systems. Depletion of T cells or neutralization of IFN-? reversed radiation-induced equilibrium, leading to tumor regrowth. We also demonstrate that PD-L1 blockade augments T cell responses, leading to rejection of tumors in radiation-induced equilibrium. We identify an active interplay between tumor cells and immune cells that occurs in radiation-induced tumor equilibrium and suggest a potential role for disruption of the PD-L1/PD-1 axis in increasing local tumor control. Twit Text FOAVip Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23630355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23630355 #FOAvip English Wikipedia <ref>{{Cite pmid|23630355 }}</ref> Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing #MMPMID23630355 Liang H ; Deng L ; Chmura S ; Burnette B ; Liadis N ; Darga T ; Beckett MA ; Lingen MW ; Witt M ; Weichselbaum RR ; Fu YX J Immunol 2013[Jun]; 190 (11 ): 5874-81 PMID23630355 show ga Local failures following radiation therapy are multifactorial, and the contributions of the tumor and the host are complex. Current models of tumor equilibrium suggest that a balance exists between cell birth and cell death due to insufficient angiogenesis, immune effects, or intrinsic cellular factors. We investigated whether host immune responses contribute to radiation-induced tumor equilibrium in animal models. We report an essential role for immune cells and their cytokines in suppressing tumor cell regrowth in two experimental animal model systems. Depletion of T cells or neutralization of IFN-? reversed radiation-induced equilibrium, leading to tumor regrowth. We also demonstrate that PD-L1 blockade augments T cell responses, leading to rejection of tumors in radiation-induced equilibrium. We identify an active interplay between tumor cells and immune cells that occurs in radiation-induced tumor equilibrium and suggest a potential role for disruption of the PD-L1/PD-1 axis in increasing local tumor control. |*Cytotoxicity, Immunologic [MESH] |Animals [MESH] |B7-H1 Antigen [MESH] |CD8-Positive T-Lymphocytes/immunology/metabolism [MESH] |Cell Proliferation [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Immunotherapy [MESH] |Interferon-gamma/immunology/metabolism [MESH] |Mice [MESH] |Neoplasm Metastasis [MESH] |Neoplasms/*immunology/pathology/surgery [MESH] |Programmed Cell Death 1 Receptor [MESH] |Radiosurgery [MESH] |T-Lymphocytes/*immunology [MESH]Radiation-induced equilibrium is a balance between tumor cell prolifer(epmc).pdf DeepDyve Pubget Overpricing