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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Hypertens
2013 ; 26
(6
): 808-15
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Alterations in diastolic function in masked hypertension: findings from the
masked hypertension study
#MMPMID23446956
Oe Y
; Shimbo D
; Ishikawa J
; Okajima K
; Hasegawa T
; Diaz KM
; Muntner P
; Homma S
; Schwartz JE
Am J Hypertens
2013[Jun]; 26
(6
): 808-15
PMID23446956
show ga
BACKGROUND: In a prior study of patients with diabetes, diastolic function was
similarly impaired in masked hypertension (MHT) and sustained hypertension (SHT).
We evaluated whether MHT is associated with impaired diastolic function compared
with SHT and sustained normotension (NT) in the general population. METHODS: From
February 2005 to December 2010, 798 participants without a history of
cardiovascular disease or treated hypertension, were enrolled in the Masked
Hypertension Study. Participants underwent clinic blood pressure (CBP) and
24-hour ambulatory blood pressure (ABP) measurements. A 2-dimensional Doppler
echocardiogram was performed to evaluate diastolic function,s cardiac structure,
volume, and systolic function. The 9 CBPs obtained across 3 clinic visits and
awake ABP measurements were averaged. Clinic hypertension was defined as
systolic/diastolic blood pressure (SBP/DBP) ? 140/90 mmHg. Ambulatory
hypertension was defined as awake SBP/DBP ? 135/85mm Hg. MHT was defined as
having ambulatory but not clinic hypertension. White-coat hypertensives (n = 8)
were excluded from the analysis. RESULTS: Of the 790 participants, 116 (14.7%)
participants had MHT, 37 (4.7%) participants had SHT, and 637 (80.6%)
participants had NT. After age, sex, race/ethnicity, and body mass index
adjustment, compared with NT, E'-velocities were significantly lower in MHT (P <
0.01) and SHT (P < 0.05), and E/E' ratios were significantly higher MHT (P <
0.05) and SHT (P < 0.05). These associations were independent of left ventricular
mass. Diastolic function parameters did not significantly differ between MHT and
SHT. CONCLUSIONS: Diastolic function was impaired in MHT compared with NT
independent of changes in left ventricular mass.